Search
Now showing items 1-10 of 189
Identification and characterization of novel mammalian alcohol dehydrogenases
(2002-08-30)
polymorphisms were detected within the 5'-flanking region. A reporter gene assay showed a significant reduction in promoter activity for a rare C+9 g T+9 transition, which could arise from decreased binding of nuclear proteins, as indicated by electrophoretic...
Pharmacogenetics of drug metabolizing enzymes with special emphasis on Ethiopians
(2003-02-14)
an Ala443Gly (m5) amino acid substitution. In total, 5 missense SNPs were found yielding in total 32 possible CYP1B1 haplotypes. However, we could only find 7 of them carrying 1-4 different missense SNPs. Functional characterization of these revealed...
Multiple sclerosis linkage analysis and DNA variation in a complex trait
(2004-01-23)
in the single marker TDT.
In study IV we investigated the gene encoding C5a located in the area of interest from study II. The anaphylatoxin C5a is a potent inflammatory mediator of the complement system, a key component of the innate immune system. Two...
Approaches for the localization and identification of human cancer genes
(2002-09-18)
approach.
Using extensive genetic approaches, we characterized a novel translocation t(1;3)(q32;q13.3) associated with familial renal cell carcinoma. By FISH mapping, the breakpoints were refined to a 5 cM region in 3q13.3 and a 3.6 cM region in 1q32. We...
Clinical differentiation between frontotemporal dementia and Alzheimer's disease : psychometric, behavioral, neuroimaging and neurophysiological information
(2002-11-29)
of behavioral observations (5 items), and neuropsychological tests (5 tests). The hit rate of the set of behavioral items was very high, 97%. These abnormal behaviors were more pronounced in FTD than in AD. The hit rate for the psychometric predictors...
Genetic dissection of multifactorial disease models in the rat
(2002-08-26)
weight. The first genome-wide scan with 253 markers revealed three glucose-related loci, Niddm I (LOD 11), Niddm2 (LOD 4.5) and Niddm3 (LOD 4.6), and one locus, Weight1 (LOD 6.2), for body weight on chromosomes 1, 2, 10, and 7 respectively, supporting...
The elite cross-country skier : clinical and sports related functional tests, dance training, injuries and self-related health
(2003-03-14)
The general aim of this thesis was to study cross-country skiers regarding the effect of dance training on joint mobility and muscle flexibility of the spine, hip and ankle and on speed and agility. Another aim was to ...
Nephrotic syndrome in children : functional, morphological and therapeutical aspects
(2003-03-21)
(s-albumin concentration) we evaluated 119 children who had various types of the nephrotic syndrome. The renal function was determined at additional times according to the clinical course of the nephrotic stage, the recovery stage and in remission...
Biological correlates of HIV-1 heterosexual transmission
(2003-11-24)
HIV-1 infection is a sexually transmitted disease but HIV transmission efficiency by sexual contacts appears to be highly variable; this is probably due to the influence that several behavioural, clinical and biological ...
Experimental studies on effects of orthodontic forces in generation of immune responses : possible roles for immunoregulating molecules in the control of alveolar bone remodeling
(2004-08-05)
The transformation of orthodontic forces to periodontal tissues involves
several biological mechanisms, which ultimately result in bone
remodelling. It has been suggested that the immune system plays a role in
the ...