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Stiffness changes of the tympanic membrane in otitis media
(2002-05-03)
Acute purulent otitis media and otitis media with effusion, are common
diseases in childhood. Years later some of the children will get
"complications", such as retraction pockets and cholesteatoma, that often
need advanced ...
Voltage sensor movements in shaker and HCN channels
(2003-11-14)
Voltage-gated ion channels are crucial for electrical signaling in living organisms. They are composed of four similar subunits with six transmembrane α-helices, S1-S6. Each subunit contains a voltage-sensing domain, S1-S4, ...
Risky alcohol consumption in the workplace : the feasibility of early detection and brief intervention as a part of routine health examinations
(2002-03-27)
There are a number of reasons why workplaces should focus on problems related to alcohol use and misuse. These include the associated risk of greater ill-health, accidents leading to injury, absenteeism, and negative effects ...
Studies on growth hormone regulation of the CYP2C12 gene in rat liver
(2003-01-09)
with a sequential binding mechanism, as described for hGH. When hepatocytes were treated with a site 2 mutant, G118RrGH, an unexpected agonistic effect was observed. The lack of antagonism together with the difficulty in achieving bell-shaped dose...
Ultraviolet radiation and cornea
(2002-03-01)
Background: Acute exposure of the mammalian eye to UVR results in development of photokeratitis after a period of a few hours. Chronic exposure to UVR is associated with an increased risk of several corneal disorders, ...
Exposures in utero and chronic disease : an alternative methodological approach
(2002-08-30)
of 132 discordant twin pairs and 118 individual twins were obtained from birth records. In comparisons between cases and sex and age-matched external (i.e., not related) twin controls, cases had significantly lower birth weight, birth length, and head...
HIV-1 infection in Tanzania : HIV antibody testing strategies and lymphocyte subset determinations
(2003-04-16)
measured in HIV-1 infected mothers. Among 138 HIV-1 seropositive mothers 20.7% transmitted HIV infection to their offspring. Mothers with CD4+ T lymphocytes <20% and beta-2M > 2.0 mg/I had a significantly higher rate of MTCT of HIV-1 infection (54%). HIV-1...
Analyses of the expression and function of the aspartic protease napsin
(2004-04-02)
hybridization showed its expression to be localized to the type II pneumocytes of the lung, from which primary lung adenocarcinoma arises. Napsin mRNA expression was examined by in situ hybridization using 118 lung tissues including 39 primary lung...
Anterior cruciate ligament reconstruction : patellar tendon, Gore-Tex, Kennedy LAD and tibia tunnel ingrowth
(2003-04-18)
between ACL reconstruction performed with the use of autogenous patellar-tendon graft or a weaker autogenous graft that was augmented with a polypropylene braid. At follow-up after 4 and 7 years, respectively, we found no statistical difference...
Beta-chemokine and CD8+ T-cell noncytotoxic anti-HIV/SIV activity
(2003-11-07)
A small number of individuals remain uninfected despite repeated exposure to HIV. A number of viral and host factors are thought to account for this resistance. The cell-mediated immune response is likely to be important ...