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Pathogenesis of myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis in DBA/1 mice
(2001-12-21)
).
Investigation of CD4 cell deficient mice (CD4-/-) and CD8 cell deficient mice (CD8-/-), as well as of wild type DBA/ 1 mice depleted of either CD4+ T cells or CD8+ T cells, highlighted the role of CD8+ T cells in MOG-induced EAE. Co-administration of PT appeared...
Pregnancy related risk factors for breast cancer
(2003-12-19)
Pregnancies offer a life-long reduction in breast cancer risk. It has
repeatedly been shown that both number of pregnancies and age at first
birth affect the future breast cancer risk. The mechanisms for this
protection ...
Neuromechanical control of the spine
(2003-05-23)
Control of the spine is complex. The spine is inherently unstable and dependent on the contribution of muscles. Yet there is considerable redundancy in the motor system with many muscles that act on the trunk.
This ...
Methods for early diagnosis of head and neck cancer
(2004-04-28)
Head and Neck squamous cell cancer (HNSCC) is the fifth most common malignancy in the western countries and in Sweden it comprises 2- 3% of all cancer cases. Alcohol and tobacco are known as principal etiological factors ...
Depression, coronary artery disease and change of lifestyle
(2001-11-29)
Depression has been identified as a risk factor for the development of coronary artery disease (CAD) and has been associated with functional impairment and disability, poor outcome of lifestyle changes, incomplete and ...
Molecular aspects of glutathione synthetase deficiency
(2004-02-27)
are rare, the most frequent disease is caused by mutations in the GS encoding gene (GSS) located on chromosome 20q11.2. Approximately 30 different mutations have been reported from a total of nearly 70 patients. Patients with GS deficiency present with a...
Significance of polymorphisms in human xenobiotic metabolising enzymes
(2002-12-20)
with the CYP1A1(*1/*2A, *2A/*2A, *1/*2B), NQO1(*1/*2, *2/*2) and GSTM1(*0/*0) variant genotypes were suggested to have an increased risk for certain histological subtypes. Stratification by cumulative smoking dose indicated that the risks associated...
On characterisation and diagnosis of frontotemporal lobar degeneration syndromes : with special reference to the progressive aphasias
(2002-09-19)
separated the TLA group from patients with AD. Four of the six TLA patients were followed longitudinally showing the mean annual bilateral decrease of temporal lobe volumes to be 9% for the left side and 8% for the right.
The possibility to use new...
Functional analysis of genetic variants in putative low penetrate breast cancer genes
(2004-09-03)
for breast cancer susceptibility. Using PCR-SSCP, we screened for germline BACH] mutations with 29 breast cancer families linked to 17q22 and additional 95 familial breast cancer cases, which were all without detectable BRCA112 mutations. No mutation...
Candidate gene analyses and genome-wide screens in multiple sclerosis
(2002-11-29)
Specific disease causing mutations have been identified for many disorders. Most of these disorders are of Mendelian origin and there have been very few successful attempts in the genetic dissection of complex traits. ...