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Undergoing stem-cell transplantation : patients perceptions of symptoms, functional status and health-related quality of life
(2002-05-24)
(T l), the day of the stem-cell infusion (T2), the day when the protective-care period started, i.e. neutrophil count < 0.5 x 109/litre (T3), the mid-point of the protective-care period (T4), the day when the protective-care period ended (T5), the day...
Functional analysis of ATM with relevance for primary immunodeficiency and tumor formation
(2004-04-08)
Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by cerebellar degeneration with ataxia, ocular and cutaneous telangiectasias, radiosensitivity, chromosomal instability, immunodeficiency, and ...
Regulation of B cell motility and adhesion in health and disease
(2003-11-07)
Migration and adhesion of lymphocytes are crucial to induce an efficient immune response. These activities rely on cytoskeletal dynamics, mediated by assembly of actin and microtubuli monomers leading to changes in cell ...
Studies on the molecular mechanisms of resistance to fluoroquinolones and carbapenems in selected bacterial species
(2003-09-05)
The emergence of mutant bacteria with multi-resistant phenotype, no longer responsive to any of the available therapeutic agents is a growing concern. We have investigated the resistance mechanisms to two classes of ...
Social differences in injury risk in childhood and youth : exploring the roles of structural and triggering factors
(2003-03-21)
Injuries are a leading cause of mortality and morbidity among children and adolescents. Injury risks are not randomly distributed across social groups. The primary aim of this thesis is to increase knowledge about the ...
On spinal mechanisms for reflex control in man : modulation of Ia-afferent excitation with changes in muscle length, activation level and fatigue
(2004-03-26)
To control muscle force, neural activation has to take alterations in
muscle mechanics into account. This thesis assesses modulations in
excitatory efficacy of Ia-afferents during muscle length changes at
different ...
Approaches for the localization and identification of human cancer genes
(2002-09-18)
to functions of cell adhesion, immune response, cell cycle, signal transduction, and fatty acid metabolism. We also compared the expression patterns of FTCs with and without PAX8-PPAR gamma 1 fusion oncogene, and the clustering analysis separated the two tumor...
Genetic studies of atopic dermatitis
(2001-11-22)
, using a non- parametric affected relative pair method. In the analysis 109 pedigrees were included, forming 193 affected full-sib pairs and 9 affected half-sib pairs (470 individuals). We also studied linkage and association to six chromosomal regions (2...
Gene mapping of atopic dermatitis
(2001-11-14)
in 109 pedigrees forming 193 full-sib pairs and 9 half-sib pairs affected with atopic dermatitis. In total, five chromosome regions reaching the level for suggestive linkage (p<7.4x10-4) were identified. Four of these chromosome regions: 3q, 13q14, 15q14...
Pulmonary tuberculosis and HIV interaction in a setting with a high prevalence of HIV : clinical, diagnostic and epidemiological aspects
(2002-05-17)
and HIV endemic area.
Among 509 consecutive out-patients attending a university hospital in Ethiopia, 33.0% were culture-verified as having PTB. PTB patients, non-TB patients and controls were HIV-1 positive in 57.1%, 38.5% and 8.3% of cases...