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Linkage and association analysis in multiple sclerosis
(2001-09-03)
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, which is characterized by relapsing or progressive demyelinating plaques in the brain and spinal cord. It is well established that ...
Observations on essential biochemical data profile in connection with restorative proctocolectomy in humans : vitamin B12 and fat absorption cited
(2001-10-18)
PATIENTS: The material includes 99 patients who consecutively received
handsawn pouch and ileoanal anastomosis, after mucosectomy. Sixty-five
patients were men and forty-four were women. The mean-age was 31.4 (range
17-59) ...
Factors affecting attendance at population-based mammography screening
(2002-01-11)
The aim of the studies described in this thesis was to explore factors affecting attendance at outreach mammography screening, and to assess possible associations between socioeconomic factors and breast cancer ...
Genetic dynamics of HIV-1 : recombination, drug resistance and intrahost evolution
(2004-05-14)
A striking characteristic of HIV is the enormous capacity of genetic
variation. Frequent mutations, deletions, insertions and recombination
events create a population of genetically related but non-identical
viruses ...
Mitochondrial dysfunction and alterations of brain HMPAO SPECT in depressive disorder : perspectives on origins of 'somatization'
(2004-04-21)
A range of somatic symptoms are more common in patients with major
depression than in the general population. Similar somatic symptoms and
depression have been described in mitochondrial disorders, in which
decreased ...
Appetitive and consummatory ingestive behavior : role of taste, dopamine and NPY
(2001-11-23)
The present thesis has examined the role of taste, dopamine and
neuropeptide Y (NPY) in the regulation of the two phases of ingestive
behavior: appetitive (approaching and handling of food) and consummatory
ingestive ...
Particles in small airways : mechanisms for deposition and clearance and pharmacokinetic assessments of delivered dose to the lung
(2004-04-16)
BACKGROUND: Knowledge about lung deposition and clearance from airways of inhaled particles/drugs are essential for evaluation of health effects of inhaled
pollutants and to achieve optimal drug dose to the lung. The ...
Diabetes mellitus, glucose abnormalities and acute coronary syndromes : studies on prevalence, risk and impact of treatment
(2003-05-23)
Background: Persons with diabetes mellitus and impaired glucose tolerance are at increased risk for cardiovascular disease.The prevalence of known diabetes among patients with acute myocardial infarction, about 20%, is ...
Clonidine in paediatric anaesthesia : pharmacokinetic and pharmacodynamic aspects
(2002-04-12)
Clonidine is a mixed alpha-2/alpha-1 adrenoceptor agonist. It reduces sympathetic and increases parasympathetic tone which results in a lowering of the baseline blood pressure and heart rate. Descending posjunctional ...
Studies on the inflammatory response in experimental acute pyelonephritis and its importance for the development of renal scarring
(2002-01-08)
Acute pyelonephritis especially in childhood is a serious and globally common bacterial infection. The infecting microorganism is often derived from the patient's own bowel flora and mainly affects the renal parenchyma and ...