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Chromatin remodelling and gene regulation
(2001-04-06)
Chromatin plays an important role in gene regulation, as it forms an obstacle for a number of proteins that need access to the DNA. Several protein complexes that open up the chromatin structure have been identified and ...
Genetic and biochemical characterization of a novel sensor of extracellular amino acids in yeast
(2001-01-26)
and compartmentalization of amino acids led to the isolation of a unique member of the amino acid permease family, SSY1, and two additional components PTR3 and SSY5. Ssy1p has a unique, extended N-terminal domain that is not present in other amino acid permeases. Ssy5p...
Factors influencing the turnover of olfactory receptor neurons
(2000-12-29)
of apoptotic cell death of both immature and mature olfactory receptor neurons in the adult, uninjured rat olfactory epithelium could be demonstrated. The number of TUNEL-labeled neurons was significantly increased 1.5 days after transection of the olfactory...
Molecular endocrinology of target enzymes in androgen metabolism : implications for prostate cancer
(2001-03-02)
Genes that are responsible for variations in drug and hormonal responses
are sometimes also associated with the pathophysiology of diseases.
Understanding the aetiology of a disease is often essential for the
design of ...
Vocational rehabilitation of unemployed sick-listed people in a Swedish rural area : an individual-level study based on social insurance data
(2000-11-28)
The long trend of low unemployment and increasing economic growth in Sweden was broken in the early 1990 s. In a short time, the rate of unemployment had risen from 1.3% in 1990 to 8.2% in 1993. A previous study made in ...
Preeclampsia and other circulatory diseases during pregnancy : etiological aspects and impact on female offspring
(2001-03-01)
The aims of this thesis were to investigate and compare environmental effects on the liability of developing preeclampsia and gestational hypertension; to estimate the relative importance of genetic and environmental effects ...
Regulation of virulence gene expression in Staphylococcus aureus
(2000-11-24)
-independent mechanisms. The effector of the sar locus is a 14.7 kDa DNA binding protein, SarA. In animal models of infection both agr and sarA have been shown to affect virulence. How RNAIII and sarA function at the molecular level is, however, poorly understood...
On vascular endothelial growth factor B and platelet-derived growth factor C : two members of the VEGF/PDGF family of growth factors
(2001-03-30)
Vascular endothelial growth factors (VEGFs), platelet-derived growth factors (PDGFs) and their receptors are important for normal development. They have also been implicated in many pathological conditions. VEGFs have been ...
Molecular diversity in the Notch receptor family
(2001-05-18)
corroborate these results. First, HES-5 expression is reduced in transgenic mice that misexpress the Notch3 IC in the neural tube, indicating that Notch3 IC also in vivo can affect Notch1 mediated activation of HES-5 (Paper I). Second, disruption of Notch1...
Pharmacological and hormonal effects on bone with emphasis on osteoporosis : experimental studies in the rat
(2001-02-23)
In this thesis influences of some hormones (17beta-estradiol and human
parathyroid hormone) and drugs (risedronate and verapamil) on bone were
investigated.
The effects of verapamil, a phenylalkylamine calcium ...