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Preeclampsia and other circulatory diseases during pregnancy : etiological aspects and impact on female offspring
(2001-03-01)
The aims of this thesis were to investigate and compare environmental effects on the liability of developing preeclampsia and gestational hypertension; to estimate the relative importance of genetic and environmental effects ...
Vocational rehabilitation of unemployed sick-listed people in a Swedish rural area : an individual-level study based on social insurance data
(2000-11-28)
The long trend of low unemployment and increasing economic growth in Sweden was broken in the early 1990 s. In a short time, the rate of unemployment had risen from 1.3% in 1990 to 8.2% in 1993. A previous study made in ...
Molecular endocrinology of target enzymes in androgen metabolism : implications for prostate cancer
(2001-03-02)
Genes that are responsible for variations in drug and hormonal responses
are sometimes also associated with the pathophysiology of diseases.
Understanding the aetiology of a disease is often essential for the
design of ...
Pharmacological and hormonal effects on bone with emphasis on osteoporosis : experimental studies in the rat
(2001-02-23)
In this thesis influences of some hormones (17beta-estradiol and human
parathyroid hormone) and drugs (risedronate and verapamil) on bone were
investigated.
The effects of verapamil, a phenylalkylamine calcium ...
Molecular diversity in the Notch receptor family
(2001-05-18)
We have studied the Notch family of transmembrane receptors, which play a crucial role in cell fate determination. The Notch signalling pathway represents a conserved mechanism to mediate signalling between adjacent, ...
Mapping of the specificity in MHC class I recognition by natural killer cells
(2000-11-24)
binding cleft (absent in Dd , present in Db ), created by amino acids at positions 73 and 156, ii) a solvent exposed loop (present in both alleles, but creating distinct motifs in each of them), formed by residues 1 02-1 09. The mutations introduced...
Renal cell cancer : the role of physical activity and body size
(2001-02-02)
The aim of this thesis was to explore how physical activity, obesity, weight change, and birth weight influence the risk of renal cell cancer.
The relation between occupational physical activity and risk of renal ...
At work in spite of pain : prevention and rehabilitation in two predominantly female workplaces, their effects and further development of analysis methods
(2001-04-04)
The overall aim of the thesis is to study the effects of preventive and
rehabilitative interventions for employees at work despite pain at
predominantly female workplaces, and further development of analysis
methods.
The ...
Studies on mechanisms of busulphan cytotoxicity and pharmacokinetics : with special reference to liposomal busulphan
(2001-04-13)
Busulphan is an alkylating agent currently used in conditioning regimen
prior to stem cell transplantation (SCT). High dose therapy with
busulphan has been shown to contribute to transplantation-related
toxicities, such ...
Risk factors for prostate cancer : analysis of primary data, pooling, and related methodological aspects
(2015-11-18)
Prostate cancer is the second most common cancer among men worldwide, yet its etiology remains
poorly understood. Obesity, on the other hand, is a prevalent but preventable medical condition that is
associated with ...