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Chromatin remodelling and gene regulation
(2001-04-06)
Chromatin plays an important role in gene regulation, as it forms an obstacle for a number of proteins that need access to the DNA. Several protein complexes that open up the chromatin structure have been identified and ...
Genetic and biochemical characterization of a novel sensor of extracellular amino acids in yeast
(2001-01-26)
Eukaryotic cells make developmental decisions that initiate distinct programs of gene expression. In the yeast Saccharomyces cerevisiae the majority of decisions affecting developmental outcomes are made in response to ...
Molecular endocrinology of target enzymes in androgen metabolism : implications for prostate cancer
(2001-03-02)
Genes that are responsible for variations in drug and hormonal responses
are sometimes also associated with the pathophysiology of diseases.
Understanding the aetiology of a disease is often essential for the
design of ...
Vocational rehabilitation of unemployed sick-listed people in a Swedish rural area : an individual-level study based on social insurance data
(2000-11-28)
of this study was therefore to investigate the unemployed long-term sick-listed and their vocational rehabilitation in a rural area of the county of Jämtland, Sweden. The study is based on a sample of 4 394 long-term sick-leave cases reported sick at all seven...
Preeclampsia and other circulatory diseases during pregnancy : etiological aspects and impact on female offspring
(2001-03-01)
The aims of this thesis were to investigate and compare environmental effects on the liability of developing preeclampsia and gestational hypertension; to estimate the relative importance of genetic and environmental effects ...
Pharmacological and hormonal effects on bone with emphasis on osteoporosis : experimental studies in the rat
(2001-02-23)
In this thesis influences of some hormones (17beta-estradiol and human
parathyroid hormone) and drugs (risedronate and verapamil) on bone were
investigated.
The effects of verapamil, a phenylalkylamine calcium ...
Molecular diversity in the Notch receptor family
(2001-05-18)
We have studied the Notch family of transmembrane receptors, which play a crucial role in cell fate determination. The Notch signalling pathway represents a conserved mechanism to mediate signalling between adjacent, ...
On vascular endothelial growth factor B and platelet-derived growth factor C : two members of the VEGF/PDGF family of growth factors
(2001-03-30)
Vascular endothelial growth factors (VEGFs), platelet-derived growth factors (PDGFs) and their receptors are important for normal development. They have also been implicated in many pathological conditions. VEGFs have been ...
Renal cell cancer : the role of physical activity and body size
(2001-02-02)
The aim of this thesis was to explore how physical activity, obesity, weight change, and birth weight influence the risk of renal cell cancer.
The relation between occupational physical activity and risk of renal ...
At work in spite of pain : prevention and rehabilitation in two predominantly female workplaces, their effects and further development of analysis methods
(2001-04-04)
The overall aim of the thesis is to study the effects of preventive and
rehabilitative interventions for employees at work despite pain at
predominantly female workplaces, and further development of analysis
methods.
The ...