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Skin sensitivity testing : a biophysical approach
(2002-04-12)
into four groups on the basis of age and gender.
In paper III, nickel sulphate in distilled water at various concentrations (0.15%, 0.31%, 0.62%, 1.25% and 2.5%) and 2% SLS were used to induce contact dermatitis of allergic and irritative type by using...
Experimental design of phenotyping probe drugs with emphasis on CYP1A2 : their use in studies on genetic and environmental regulation of drug metabolism
(2003-05-02)
=0. 82) and the urinary ratio of N-3-demethylated metabolites / caffeine collected for 8 or 24 hours (rs=0.63-0.70). The use of a 36-hour caffeine abstinence period was appropriate to avoid the influence of caffeine ingested before the study...
Langerhans cell histiocytosis : detection, monitoring and pathophysiology
(2002-04-26)
Langerhans cell histiocytosis (LCH) is a rare disease that may occur at any age but mainly affects children. Clonally expanded Langerhans cells together with lymphocytes, eosinophils and macrophages form destructive ...
Mortality and cancer incidence following cerebral angiography with thorotrast
(2002-08-30)
).
Patients exposed to Thorotrast had a significant three-fold increase in overall mortality compared to the general population (standardized mortality ratio=SMR 2.8), with similar excesses for men and women. The largest risks were observed for deaths from...
Quality of life in patients with malignant blood disorders : a clinical and methodological study
(2002-10-25)
The overall aim of this thesis was to evaluate and, improve measurements of, health-related quality of life (HRQL) in patients with malignant blood disorders. Patients undergoing autologous stem cell transplantation (SCT), ...
Endocrine and metabolic aspects of adult Prader Willi syndrome with special emphasis on the effect of growth hormone treatment
(2003-09-05)
Prader Willi Syndrome (PWS) is a complex genetic disorder characterized by muscular hypotonia, hyperphagia, obesity and behavioural problems. Partial growth hormone (GH) deficiency and hypogonadism are common. Results of ...
Autoimmune markers in autoimmune diabetes
(2003-12-19)
Type 1 diabetes mellitus (T1DM) is an autoimmune disease, characterized by autoimmune mediated loss of insulin secreting Beta-cells. The disease is associated with certain HLA class 11 haplotypes. HLA DR3-DQ2 and DR4-DQ8 are positively while DQ6...
Method development for analysis of 8-oxodG as a biomarker for oxidative stress
(2001-11-22)
-irradiation. Oxidation of DNA bases occurs mainly at dG,
giving stable DNA adducts such as 8-oxodG and FapydG.
The use of 8-oxodG as a biomarker (expressed as the ratio 8-oxodG/dG)
requires well- controlled workup conditions because 8-oxodG can be formed
during...
Quality of life and femoral neck fractures
(2002-11-27)
The worldwide increase of hip fractures is a major challenge for the health care system and society. The treatment of femoral neck fractures in the elderly is still controversial, and even more so from an international ...
Functional and bioinformatical studies of the TGFb superfamily : identification and characterization of ALK7
(2001-11-02)
The transforming growth factor beta (TGFbeta) superfamily of polypeptide
growth factors encompasses more than 30 diverse mammalian members. They
are involved in most cellular processes, ranging from cell proliferation
and ...