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Crystallographic studies of gluconate kinase
(2001-11-23)
The first steps of gluconate metabolism in Escherichia coli are the transport of gluconate into the cell by a gluconate transport system, followed by phosphorylation to gluconate-6- phosphate by gluconate kinase. There ...
Undergoing stem-cell transplantation : patients perceptions of symptoms, functional status and health-related quality of life
(2002-05-24)
was suffering from. From the day of the stem-cell infusion (T2) and up to approximately 10 days after the transplantation (T5), between 33 % and 54% of the patients reported > 10 simultaneous symptoms. Tiredness (81-91%), loss of appetite (88-93%) and mouth...
Voltage sensor movements in shaker and HCN channels
(2003-11-14)
-conducting pore domain, S5-S6. S4 contains several positively charged residues and moves in response to changes in the transmembrane voltage. This movement controls the opening and the closing of the ionconducting pore. The structure of the pore domain...
Skin sensitivity testing : a biophysical approach
(2002-04-12)
and visual evaluation.
In paper I, sodium lauryl sulphate solutions (SLS) (0.1-5.0%) and a blank were applied to the skin of 10 healthy volunteers.
In paper II, readings were taken from ten regions over the body in 131 healthy volunteers, divided...
Use of primary human hepatocytes for the elucidation of bile acid synthesis
(2003-01-03)
was defined in the hepatocytes including 7alpha, 12alpha, 27-trihydroxy-4-cholesten-3 -one, 7alpha,12alpha-dihydroxy-3-oxo-4-cholestenoic acid and 7alpha,12alpha-dihydroxy-3oxo-5beta-cholanoic acid as intermediates.
· The oxysterol 24S...
Biophysical aspects of contact dermatitis and its prevention
(2004-03-05)
, patch tests with 0.5% and 2% NiSO4 in petrolatum were done on the forearm of 20 nickel-allergic patients and five healthy subjects, which had been pre-treated with a urea-containing moisturiser. Skin areas that had not been pre-treated were used...
Nasal and bronchial airway reactivity in allergic and non allergic airway inflammation
(2003-01-24)
In allergic or asthmatic airways disease, upper and lower airways show a uniform eosinophilic inflammation of the mucosa, and bronchial hyperreactivity is a common finding. To study the co- variation of mucosal reactivity ...
Pulmonary tuberculosis and HIV interaction in a setting with a high prevalence of HIV : clinical, diagnostic and epidemiological aspects
(2002-05-17)
and HIV endemic area.
Among 509 consecutive out-patients attending a university hospital in Ethiopia, 33.0% were culture-verified as having PTB. PTB patients, non-TB patients and controls were HIV-1 positive in 57.1%, 38.5% and 8.3% of cases...
Tuberculosis and HIV interaction in Ethiopian children : aspects on epidemiology, diagnosis and clinical management
(2002-08-30)
, consecutively enrolled as out- and
inpatients at the major paediatric hospital in Addis Ababa, Ethiopia.
The first study identifies HIV as a major risk factor for TB. HIV
prevalence among tuberculous children in Addis Ababa was 12.5%, compared
with 1.6% among...
Health economic assessment of medical technology in chronic progressive diseases : multiple sclerosis and rheumatoid arthritis
(2003-09-26)
data. The models based on two independent epidemiological cohorts of newly diagnosed patients in Sweden and the UK showed a strikingly similar outcome, with patients having an average of 5.1 QALYs over 10 years. However, costs were very different, due...