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The rational use of drugs in a population of very old persons
(2002-02-28)
This thesis investigated the use of drugs in a population of very old
persons. The pattems of use, particularly of psychotropic drugs, and its
appropriateness were assessed. Drug use was also assessed according to
dementia ...
Allogeneic stem cell transplantation in children : identification and prevention of complications : adoptive transfer of EBV-immunity
(2003-01-24)
grafts. The 5-year probability of survival was 52 % for MUD vs. 77% for sibling recipients (p= 0.014). In ALL, the survival of the MUD (77%) and sibling group was equal. In SAA, survival was 43% vs. 86% (p=0.09) and in metabolic disorders 63% vs. 89% (p=0...
Langerhans cell histiocytosis : a clinical and immunological study
(2003-02-21)
-yr survival of 77% (17/22) in multi-system disease was significantly lower as compared to the 100% (27/27) survival of children who had singlesystem disease at diagnosis (p=0.014). Late sequelae of the disease or its treatment had developed in 42...
Clinical and genetic investigation of hypochondroplasia and dyschondrosteosis
(2001-09-07)
Linear body growth is a multifactorial trait influenced by many environmental and intrinsic factors. Among the intrinsic determinants of body height, genetic and endocrine factors are considered to be the most important. ...
Atherosclerosis of the ascending aorta as a risk factor for stroke after cardiac surgery : a study based on epiaortic ultrasound
(2004-04-23)
% of the ascending aorta diseased and those with more than 50% affected
were 95.3±0.9%, 91.8±2.1% and 65.0±14.6%, respectively (p<0.0001). The
distal-left side of the ascending aorta was associated with a 5-fold
increase in 5-year stroke rate.
Conclusions...
Functional genomics at the interface of protein expression and biophysical analysis
(2004-02-18)
Protein characterization is central to any functional genomics effort, hence protein expression and purification play fundamental roles in these initiatives. In this study strategies for protein expression in E. coli were ...
Regulation of germline transcription in the immunoglobulin heavy chain locus
(2004-08-13)
During an immune response, activated B cells develop into high rate immunoglobulin (Ig) secreting plasma cells. They also switch from production of IgM to IgG, IgA or IgE. Specific isotypes of antibodies have functional ...
Bile in the oesophagus contributes to the development and complications of gastro-oesophageal reflux disease
(2002-05-10)
Objective: To clarify the relationship between duodenogastro- oesophageal reflux (DGOR) and gastro- oesophageal reflux disease (GORD) and its complications.
Methods: As persons who have had their gallbladders removed ...
Development of a new PNA analogue as a potential antisense drug and tool for life-science studies
(2004-05-13)
The work described in this thesis focuses on applying synthetic organic chemistry methods (supported by modem synthesizers and analytical techniques) for the preparation of peptides and modified nucleic acids in order to ...
Birth centre care : reproduction and infant health
(2004-04-02)
This thesis has two general aims, to investigate factors affecting
women s decision to have a second baby and to study the effect of birth
centre care on infant outcome. The specific aims were to investigate 1)
whether ...