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Pharmacodynamics of low-dose clonazepam in children with epilepsy or spasticity : neurophysiological and clinical studies
(2001-05-25)
In children with epilepsy the evaluation of the efficacy of an antiepileptic drug (AED) is usually made by recording the seizure frequency. Some seizures are subtle and difficult to detect and epileptiform activity even ...
Molecular regulation and analysis of neural stem and cancer cell characteristics
(2012-05-25)
and multipotency required for differentiation into the various cell lineages found in the mammalian CNS. Further, we show that NEIL3 deficiency can enhance formation of senescence related heterochromatin foci, suggesting an influence in regulatory functions...
Regulation of protein synthesis in human skeletal muscle : separate and combined effects of exercise and amino acids
(2014-05-22)
Skeletal muscle is a highly plastic tissue which has the ability to adapt to various forms of external stimuli such as diverse modes of contractile activity. Thus, performance of endurance exercise over several of weeks ...
Studies on meniscus surgery with focus on preservation and meniscus function
(2020-12-23)
The aim of this thesis was to investigate the effect of surgical preservation and restoration of the meniscus on knee function and outcomes. In Study I, 4497 patients with primary hamstring ACLR were evaluated regarding ...
PET studies of the serotonin system in major depression and its treatment
(2014-10-03)
The serotonin system has been implicated in major depression since the
1960s, mainly based on the serotonin enhancing properties of
antidepressants. Positron emission tomography, PET, is the in vivo
molecular imaging ...
Tumor-infiltrating lymphocytes and the PD-L1/PD-1 signaling axis in breast cancer : biology and clinical implications
(2020-04-03)
and mRNA level in the same retrospective early BC patient cohort. Both protein (stained with the antibody clone SP263) and gene expression predicted improved outcome in early BC and also correlated with enhanced T-cell infiltration (CD3+ IHC...
CYP2C-dependent drug metabolism in vivo : influence of genetics and drug interactions
(2010-11-24)
the influence of the genetic variant CYP2C9*3 on the CYP2C9 dependent metabolism of the anti-inflammatory and analgesic drug celecoxib. We found a seven-fold higher median exposure at steady-state in homozygous carriers of the CYP2C9*3 allele compared...
Immunomodulation and its effector mechanisms in atherosclerosis
(2007-05-11)
Atherosclerosis is a disease of the arterial intima, characterized by
cholesterol deposition, inflammation and fibrosis. The pathogenesis of
atherosclerosis is related to both innate and adaptive immune responses,
and ...
Immune mechanisms in atherosclerotic vascular disease
(2002-05-14)
revealed that genotype A1A2 was decreased in RA patients compared to referents, while A2A3 was increased- In contrast, there was no association of IL-1Ra polymorphisms to the development of stroke. IL-1 beta and IL-1Ra alleles of different haplotypes were...
Early-life selenium status and cognitive development
(2018-11-12)
Selenium is an essential element that is found in food sources such as meat, fish, and cereals. The essentiality of selenium was demonstrated in the 1950s, and the interest in its health effects has been growing ever since. ...