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Infections in allogeneic stem cell transplanted patients : clinical and immunological aspects
(2001-05-11)
patients with IP
showed that the immune response was dominated by activated macrophages
and increased production of pro-inflammatory cytokines (II1, TGFbeta)
Furthermore, we found Th2-type of immune response, characterised by
expression of CD86 co...
Epstein-Barr virus and genomic instability : a new look at the mechanisms of viral oncogenesis
(2010-12-20)
oxidative stress by transcriptional activation of the catalytic subunit of NADPH oxidise, NOX2. Stable or conditional expression of EBNA1 was associated with the accumulation of telomere abnormalities, including loss and gain of telomere signals, telomere...
Elucidating regulatory elements : studies in chronic lymphocytic leukemia and multiple myeloma
(2018-12-21)
background, they might present with a common epigenetic background. For this we aimed to collect paired RNA-seq, histone ChIP-seq and ATAC-seq for patients and healthy controls, and had the following specific hypotheses: 1. Using H3K4me2 and H3K27Ac, we...
Amino acid predictors of HIV-1 coreceptor use in different subtypes and their application to antiretroviral treatment
(2014-01-10)
this further, 24 treatment failure patients infected with subtype C in Botswana were in paper III compared with 26 treatment-naïve patients with regard to coreceptor use, which was determined using the coreceptor use prediction algorithm Geno2pheno with a...
Endogenous and exogenous hormonal factors in female cancers : studies of risk and prognosis
(2009-02-06)
Extensive evidence points to hormonal influences which play a critical
role in the development and progression of breast, ovarian and
endometrial or uterine cancers. These cancers share many common hormonal
features, ...
Clinical studies on drug treatment of hospitalised patients : general infectious diseases and acute myocardial infarction
(2013-05-03)
. We found that CYP2D6 is a major factor of metoprolol disposition and effects in AMI patients and also a major determinant of individual variability of response to the treatment. Common exogenous medications prescribed for treatment of depression...
The experience of being new and desirable support during the first year in the emergency medical services
(2018-10-05)
The emergency medical services (EMS) has been described as a challenging professional practice where the persons in need of care vary greatly in terms of age, symptoms and situations. There is limited research regarding ...