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Identification and characterization of candidate genes for type 2 diabetes in the GK rat
(1999-11-10)
in postprandial glucose and insulin. The two other congenic strains, Niddm1e, and Niddm1f), exhibited similar diabetes-associated phenotypes, as Niddm1b did. This demonstrates that the diabetes locus located in Niddm1b is fine mapped to the 3.7 cM-interval carried...
Utilisation of health services in a transitional society : studies in Vietnam 1991-1999
(2001-05-16)
services than others.
For those who sought care in the lowland area, mean expenditure on
outpatient care was 7% of the mean household monthly income and 4% for
those who practised self-medication. For health facility users, the
poorest households spent...
Functional genomics studies of PINK1
(2007-10-25)
Functional genomics has become an important and established research discipline during the last 10 years, mainly as a consequence of the completion of large-scale genome sequencing projects. The human genome is now predicted ...
Molecular and epidemiological studies of bladder exstrophy and epispadias complex
(2023-04-13)
Bladder exstrophy and epispadias complex is a rare congenital genitourinary malformation involving a midline closure defect, leaving an open bladder on the lower abdominal wall.
In Sweden, the prevalence is 3:100 ...
Mathematical modelling of insulin signalling : effects on glucose metabolism in skeletal muscle
(2010-04-13)
The use of models to understand complex phenomena is indispensable to the
scientific community. The advantage of a model is that it simplifies the
phenomena under study. However, a model should be only as complex ...
Stress, depression, and other psychiatric disorders : an epidemiological approach to studying the causes and consequences for in vitro fertilization outcome and polycystic ovary syndrome
(2017-04-20)
Reproductive epidemiology, psychiatric epidemiology, and pharmacoepidemiology come together in this thesis which is comprised of four studies and divided into two parts.
Part 1 examines the impact of stress and ...
Attempted suicide and shame
(2012-02-02)
A suicide attempt constitutes not only a risk factor for suicide, but also an expression of human suffering. As therapists, physicians and caring personnel we have an opportunity to reach out to this suffering individual ...
Regulation of gene expression by non-protein-coding RNAs
(2009-01-29)
The human genome sequencing projects revealed that the human genome contains over 3 billion DNA base pairs, but only 20,000 25,000 protein-coding genes. In fact, only about 1.2% of the genome codes for proteins. Surprisingly, ...
MHC-class I restricted peptide-based immunomodulation of CD8+ T and NK cells
(2012-09-06)
The main aims of the immune system are to protect the host from potential threats by distinguishing self from non-self and altered-self. T cells and NK cells play a key role in the identification and elimination of threats ...
Notch in cancer and cancer metabolism : six degrees of intracellular turbulence
(2016-08-12)
Notch signaling is an evolutionarily conserved cell-to-cell contact-dependent signaling mechanism in multicellular organisms directing cellular fates both in early development and adult tissues. In metazoans the Notch ...