Search
Now showing items 1-9 of 9
Experimental studies on xenograft rejection
(2001-05-17)
The use of animal organs and tissues may provide a solution to the severe and worsening shortage of human grafts. The aims of the present experimental studies were to provide a better understanding of the rejection mechanisms ...
MHC-class I restricted peptide-based immunomodulation of CD8+ T and NK cells
(2012-09-06)
The main aims of the immune system are to protect the host from potential threats by distinguishing self from non-self and altered-self. T cells and NK cells play a key role in the identification and elimination of threats ...
Cardiac remodeling in aortic and mitral valve disease : a simulation study with clinical validation
(American Psychological Association, 2019-09-03)
Background: Remodeling is an important long-term determinant of cardiac function throughout the progression of heart disease. Numerous biomolecular pathways for mechanosensing and transduction are involved. However, we ...
Endogenous thrombospondin-1 and proteases in the regulation of lymphocyte adhesion and motility
(2008-09-26)
lipoprotein receptor-related protein (LRP)/CD91. Interaction of TSP-1 with its cell surface receptors calreticulin (CRT), LRP and integrin associated protein (IAP)/CD47 was promoting motility of T cells in 3D collagen through CD47. T cell surface TSP-1 also...
Cardiovascular disease risk among people living with HIV in South Central Uganda
(2022-10-21)
OR of 0.87 per one-year increase (95% CI: 0.82-0.93). Female sex (OR = 4.87, 95% CI: 2.98-7.97) and alcohol consumption (OR = 2.29, 95% CI: 1.47-3.59) were additionally found to be associated with increased odds of low HDL. In study III, participants...
Multiple roles of HMGB1 in clinical and experimental arthritides
(2012-12-12)
Inflammation can be infectious and/or sterile depending on the initiating event. The proinflammatory mediator High mobility group box protein 1 (HMGB1) is a nuclear protein released from cells during both sterile and ...
Investigating and explaining sex differences in episodic memory
(2020-05-18)
Sex differences can be seen in a lot of different areas, one of them being cognition where, among other things, men tend to perform better at more spatial tasks and women at more verbal. When it comes to episodic memory — ...
Genetic determinants of breast cancer risk
(2011-01-19)
The main purpose of this thesis was to identify genetic risk factors using both hypothesis-based and hypothesis-free approaches.
In an attempt to identify common disease susceptibility alleles for breast cancer, we ...
Regulation of cellular degradation pathways by viral oncoproteins and microRNAs
(2020-10-08)
The cellular degradation system actively participates in cell homeostasis. Despite ongoing efforts and much progress in recent years, the underlying mechanisms of these pathways are not entirely understood. This thesis ...