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Experimental autoimmune sialadenitis : studies of immunopathogenesis, cellular signaling and MHC genetics
(2001-04-24)
Experimental autoimmune sialadenitis (EAS), an animal model for Sjogren´s
syndrome (SS) in humans, develops spontaneously in certain mouse strains.
A major feature of EAS and SS is infiltration of exocrine glands ...
Radiotherapy in advanced head and neck cancer
(2023-03-17)
Head and neck cancer (HNC) is a group of malignant tumours located in the mucosa of the upper aero-digestive tract. The location of the tumour, close to several critical organs, can often result in great suffering for the ...
Trajectory mapping of human embryonic stem cell cardiogenesis reveals lineage branch points and an ISL1 progenitor-derived cardiac fibroblast lineage
(2021-02-17)
A family of multipotent heart progenitors plays a central role in the generation of diverse myogenic and nonmyogenic lineages in the heart. Cardiac progenitors in particular play a significant role in lineages involved in ...
Search for reliable diagnostic markers for Alzheimer’s disease
(2000-04-28)
The diagnosis of Alzheimer’s disease (AD) is rather difficult not at least in the earlier stages of the disease. The diagnostic accuracy has been reported to be around 65-90%. These figures however, come from academic ...
Dynamics of proteinopathies in Alzheimer’s disease as measured by PET and CSF biomarkers
(2018-10-05)
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the extracellular aggregation of the amyloid-β (Aβ; amyloid) peptide and the intraneuronal accumulation of the protein tau. Independently, and in ...
Regulatory networks of c-di-GMP signalling involved in biofilm formation, motility and host pathogen interactions in Salmonella typhimurium
(2013-08-09)
Adaptation to altered environmental conditions is one of the fundamental bacterial characteristics. The ubiquitous second messenger c-di-GMP plays a key role to adopt bacterial behaviour. Transition from motility to sessility ...
Regulation of biofilm formation in Salmonella typhimurium and Escherichia coli Nissle 1917
(2010-12-20)
Bacteria have the ability to grow in cell communities designated biofilms. This mode of growth is widespread and offers numerous advantages to the bacteria in terms of survival, persistence and propagation. Bacteria have ...
Neuroblastoma as a target for effector mechanisms of the immune system
(2007-05-24)
Neuroblastoma (NB) is the most common solid extracranial tumor in
children. Despite intensive multimodal treatment, the prognosis for
high-risk NB patients remains poor and therefore new treatment modalities
are needed. ...