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Mechanisms of impaired insulin release in type-2 diabetes : studies in the GK rat model
(1999-10-15)
Type-2 diabetes is a complex syndrome with a polygenic and multifactorial aetiology. It is characterised by its relatively late appearance in life and its mild progressive course. Glucose intolerance can generally be ...
Studies on catecholamine function in human fat cells
(1996-11-15)
Human adipose tissue is a heterogeneous organ as regards metabolism. The effects of catecholamines, the main lipolytic hormones in man vary considerably in different regions. Fat cell lipolysis also changes in a number of ...
Genetic basis of congenital nephrotic syndrome and generation of an animal model
(2001-05-11)
Congenital nephrotic syndrome, NPHS1, is a disease highly enriched in Finland with incidence of 1:8200 births. The disease is characterized by massive proteinuria, go % of which is albumin, starting in utero, large placenta, ...
Mechanisms of malignant and non-malignant angiogenesis using zebrafish models
(2010-10-01)
Pathological angiogenesis significantly contribute to the onset, development and progression of most common and severe human diseases including cancer, metastatic disease, cardiovascular disease, age-related macular ...
Hormonal regulation of HES-1 in breast cancer cells
(2008-05-21)
Hairy and Enhancer of Split homolog 1 (HES-1) is a transcriptional repressor belonging to the basic helix-loop-helix family of proteins, and has been shown to have a pivotal role as a regulator of neurogenesis, myogenesis ...
Refugees and asylum seekers : their social networks and encounter with the mental health services
(2021-11-09)
interviewed about migration experiences, perceptions of illness, health care consumption, and traumatic experiences. A biographic network map was drawn and three health assessment scales (CES-D-20, PHQ-15, MINI 5.0.0) were administered. The interviews were...
Characterization of B cell response alterations resulting from ablation of IκBNS expression
(2020-08-07)
The immune system is a sophisticated organization of cells and tissues that cooperate in safeguarding the integrity of our body by eliminating internal and external threats. Vaccines are the most impactful medical intervention ...