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HIV-2 and SIV vaccine studies in macaques : with emphasis on humoral immune responses
(2001-04-12)
This thesis describes the evaluation of HIV vaccines candidates in the
HIV-2 or SIV monkey models. The immunogenicity and protective efficacy of
the vaccines were investigated. Furthermore, correlates to protective
immunity ...
Determinants of hearing impairment in Swedish hunters : an e-epidemiological approach
(2016-04-08)
Background: 290 236 persons bought a hunting license in Sweden 2014/15. Hunters are
spread all over the country and come from all socioeconomic groups. Recreational fiearms
can produce peak noise levels between 156-164 ...
Plasma cell malignancies in Sweden : subgroup descriptions and regional outcomes for multiple myeloma
(2022-04-13)
secretion of S-FLC and M protein) constituted only 6% of patients with available S-FLC. No differences in overall survival (OS) were seen between secretory and non-measurable MM disease, or between secretory MM and the non-measurable MM subgroups. In study...
A multifactorial approach to targeting signalling pathways in diabetic foot ulcers
(2019-10-18)
Diabetic foot ulcers (DFU) are one of the most debilitating complication of diabetes that adversely impacts the health, economics and quality of life of the afflicted individual. The primary pathogenic factor of DFU is ...
Characterization of B cell response alterations resulting from ablation of IκBNS expression
(2020-08-07)
The immune system is a sophisticated organization of cells and tissues that cooperate in safeguarding the integrity of our body by eliminating internal and external threats. Vaccines are the most impactful medical intervention ...
Cost analysis and policy implications in psychiatric care
(2009-04-01)
in Sweden in 2001 (Study I) was estimated at MSEK 85 774 (M€ 9 426, €1= SEK9.1). Indirect costs were totally predominant and constituted about 80% of the total cost, i.e. production losses due to early retirement, sickness absence and premature death...
The pathophysiological roles of kynurenic acid and cytokines in psychiatric illness
(2011-09-07)
osmotic minipumps) to elevate brain kynurenic acid levels. For locomotor activity experiments, C57BL/6 mice received acute or subchronic pretreatment of L-kynurenine (10 mg/kg, i.p. or 100 mg/kg, i.p., twice daily for six days). Spontaneous and amphetamine...
Virulence in Plasmodium falciparum malaria : mechanisms of PfEMP1-mediated rosetting
(2013-11-07)
Malaria is one of the most important infectious diseases in the world and the Plasmodium falciparum parasite is the causative agent of most of the severe cases. The pathogenesis of the disease is complex but sequestration ...
Interactions between neuroblastoma and the immune system : cellular pathways and mediators
(2011-03-04)
Neuroblastoma (NB) is an embryonal tumor of early childhood arising in tissues of the sympathetic nervous system, such as the adrenal gland and paraspinal ganglia. It is the most common extra-cranial solid tumor of childhood, ...