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Metabolism of inorganic arsenic and biomarkers of exposure
(2001-03-30)
Humans as well as most mammals metabolize inorganic arsenic (Inorg As), a
recognized human carcinogen, by methylation. The end-metabolites
methylarsonic acid (MMA) and dimethylarsinic acid (DMA) are less toxic
and more ...
Customization of tamoxifen therapy : not only a dream
(2011-09-06)
as the sole adjuvant treatment, we found a significant negative effect of high VEGF on survival. Interestingly, the effect was overcome by a prolonged tamoxifen regimen. Moreover, studies on MCF7 cells and its 4-hydroxytamoxifen (4-OHT)-resistant counterpart...
Studies on novel interactors in human adipose tissue
(2011-05-19)
Obesity is associated with a mild inflammation and altered protein secretion in adipose tissue. These changes have been suggested to contribute to the development of obesity-associated disorders including, insulin resistance, ...
Determination of transcription factor binding specificities
(2015-11-19)
The term "genetic code" refers to the way in which the information encoded in nucleic acids
is converted into the amino-acid sequence of proteins. There is however also a second genetic
code, one that is used by the cells ...
Genetic epidemiology of adiposity and abnormal glucose tolerance in South Asian Indians
(2013-08-12)
Genetic factors play a substantial role in susceptibility to common diseases such as type 2 diabetes (T2DM) and obesity-related disorders. The current investigation was undertaken to examine the association of genetic ...
Effect of cycline-dependent kinase and matrix metalloproteinase inhibitors on hematopoietic and leukemic cells
(2008-10-24)
and brain fitted a two-compartmentmodel in both adult and pups. Pharmacokinetics was age-dependent with a terminal elimination half-life of 7h in brain and plasma in pups compared to <0.5 h in adult rats. Brain exposure to roscovitine expressed as AUC brain...
Investigating the role of p73 proteins in controlling the tumor microenvironment
(2020-10-20)
Cancer is a multifactorial disease governed by oncogenes and tumor suppressors that not only impact on the behavior of the cancer cells but also influence many processes in the surrounding tumor microenvironment. The most ...
Impaired response to HBV vaccination in HIV-1 infected children : immunopathological mechanisms
(2018-05-08)
vaccination. The change was most likely related to vaccination since the children were on ART for a median of 7.2 years and had therefore likely reached a plateau phase for HIV-1 DNA decay after ART initiation. EM CD8+ T cells were the stronger predictors...
Basis for reclassification of nasopharyngeal carcinoma
(2012-03-22)
.6%) were histologically classified as undifferentiated epithelial cell carcinoma (UECC), 942 (24.5%) as undifferentiated mixed epithelial-sarcomatoid cell carcinoma (UESCC), 640 (16.7%) as undifferentiated sarcomatoid cell carcinoma (USCC), and 200 (5...
Association between diet and treatment results in patients with rheumatoid arthritis and systemic lupus erythematosus
(2016-11-07)
Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are chronic autoimmune inflammatory diseases. The causes of these diseases are unknown and evidence indicates that a combination of both genetic and environmental ...