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Congenital adrenal hyperplasia, CYP21 deficiency, screening and clinical aspects
(2001-03-30)
recall procedures for the screening of preterm infants were implemented in Sweden based on these findings.
11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activates cortisone to cortisol. A patient with insufficient response to treatment...
Helicobacter pylori eradication in the Swedish population
(2017-04-28)
decreased over the study period. Overall, 91.0% had 1 eradication and 0.1% had more than 3. Of all eradications, 95.4% followed the recommended regimen, while 4.7% did not. The latter group was overrepresented among individuals aged ≥80 years (7...
Modulating chromatin by transcription and nucleosome turnover : a genome-wide study in fission yeast
(2015-12-10)
Eukaryotic DNA is wrapped around histone proteins to form a nucleosome, the basic
structural unit of chromatin. Multiple levels of chromatin organization are required to
compact DNA into chromosomes, to ensure an accurate ...
Automated analysis of fetal cardiac function : a new approach based on tissue Doppler imaging
(2018-03-08)
The heart is a central organ in fetal adaptation to various hemodynamic insults and it is possible that subtle changes caused by complications such as hypoxia and anemia could manifest themselves early as altered fetal ...
Genetic studies in familial non-BRCA breast cancer
(2017-11-09)
Family history is an important risk factor for breast cancer, the presence of breast cancer in a first degree relative in general nearly doubles the risk and the risk increases with the number of affected relatives. Pathogenic mutations in BRCA1...
Cardiovascular disease in dementia
(2016-12-08)
The objective of this thesis was to characterize the burden of cardiovascular diseases in patients with dementia, their treatment and association with survival. Further, we aimed to explore whether cardiac structure in ...
Epidermal stem cells at the point of no return
(2023-05-17)
The skin is our main barrier against outside harm, and it helps to maintain internal
homeostasis. These functions are mostly fulfilled by the epidermis, which is the
outermost layer of the skin, formed from keratinocytes ...
Aspects of positive and negative mental health in young people, aged 16-29 years : measurements, determinants, and interventions
(2019-08-07)
Background: Mental health problems in young people, i.e. those self-reported as well as registered diagnoses, have been of concern for decades. For Western societies, most studies indicate a rise in symptoms, but also in ...
MicroRNAs in skin immunity and psoriasis
(2014-12-16)
-inflammatory cytokines of the IL-1 family were shown to be strong inducers of miR-146a, plausibly responsible for the miR-146a overexpression in psoriasis keratinocytes. Taken together, these results propose that miR-146a regulates skin immune responses after infection...
Development of a therapeutic vaccine against the hepatitis C virus
(2007-11-27)
recently been shown to interfere with the innate immunity through cleavage of Cardif (also known as IPS-1, MAVS, VISA), resulting in suppression of the interferon response within the infected cell. We found that cleavage of Cardif by NS3/4A also occur...