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Metabolic and endocrine function of human adipose tissue with focus on regional differences
(2001-03-16)
The major function of human adipose tissue is to store excess ingested energy and to release free fatty acids after hydrolysis of triglycerides (lipolysis), to meet the energy demands of other organs. Adipose tissue also ...
Extra- and intracellular electronic conductance of signals and its significance for synaptic plasticity
(2008-08-08)
Electrical signals play a pivotal role in the normal function of most if
not all organisms. Understanding the electrophysiological principles that
govern electrical signaling is essential for insights into normal- ...
Immune and autoimmune responses to HIV-1 in mucosa and other tissues
(1999-10-08)
The aim of these studies was to evaluate routes and devices for administration of HIV-1 DNA vaccines. In particular we were interested in mucosal routes for the induction of immunity at mucosal surfaces.
We studied ...
Glomerulopathy in normoalbuminuric adolescents with type 1 diabetes : relations between structure, function, metabolic control and ambulatory blood pressure
(2005-04-29)
An increase in the incidence of type 1 diabetes in childhood has been
reported in several countries, especially among the youngest children.
Although clinically apparent diabetic vascular disease is rare in
children and ...
Regulation of skeletal muscle metabolism and development by small, non-coding RNAs : implications for insulin resistance and type 2 diabetes mellitus
(2018-05-23)
microRNAs (miRNAs) are a class of epigenetic post-transcriptional regulators. These short (~22 nucleotides) non-coding RNAs can potently reduce protein abundance through direction of the RNA-induced silencing complex to ...
Signalling pathways controlling bacterial adaptation
(2009-03-27)
The conversion of environmental signals into cellular responses is a critically important process that occurs in all organisms. The ability to process information depends, in general, on complex signal transduction and ...
Modelling and quantifying brain connectivity and dynamics with applications in aging and ADHD
(2019-10-04)
Human brain is a complex organ and made up of integrative networks encompassing a large number of regions. These regions communicate with each other to share information involved in complex cognitive processes. Functional ...
Characterization of B cell response alterations resulting from ablation of IκBNS expression
(2020-08-07)
The immune system is a sophisticated organization of cells and tissues that cooperate in safeguarding the integrity of our body by eliminating internal and external threats. Vaccines are the most impactful medical intervention ...
International validation of the comet assay and a human intervention study
(2011-09-30)
The comet assay is an established, sensitive method extensively used in biomonitoring studies. The methods’ advantages include; a) only a small cell sample is required, b) possibility to measure damage in practically any ...