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Genetic changes in childhood acute lymphoblastic leukaemia and other lymphoid malignancies
(2001-02-23)
% can only be detected by molecular techniques.
Deletions in 6q, 9p, 13q and the translocation t(12;21) frequently resulting in loss of heterozygosity (LOH) in 12p, are examples of mutations found in ALL. Our screening of primary ALL...
Studies on anti-inflammatory and vasoactive effects of mPGES-1 inhibition
(2022-12-13)
Inflammation is the basis for various serious illnesses such as rheumatic diseases, cardiovascular diseases, and cancer. Prostaglandin E2 (PGE2) is a pro-inflammatory lipid mediator produced by cyclooxygenases (COX1/2) and ...
Consequences of outsourcing referrals for radiological examinations
(2016-11-14)
Background: Demands for ever more effective healthcare and care accessibility for all patients continue to increase the workload in diagnostic radiology departments. Along with rapid developments in imaging technology which ...
Cellular mechanisms of human muscle fatigue and disease-related loss of muscle function
(2020-08-27)
A loss of skeletal muscle function and mass is a hallmark of several diseases resulting in a dismal life quality and poor prognosis. Impaired intracellular Ca2+-handling has been proposed as an underlying cause of these ...
To cut or not to cut? Episiotomy in vacuum extraction
(2022-04-05)
. The third-degree perineal injuries alone were reduced from 14.0% to 10.9% (-3.1, 95% CI -3.7 to -2.4) with NNT 32. The fourth-degree perineal injuries alone were reduced from 1.6% to 1.0 % (-0.6%, 95% CI -0.8 to -0.4). Fourth-degree perineal injuries...
Regulators of glucose and lipid metabolism in skeletal muscle and serum : implications for obesity and type 2 diabetes
(2012-11-01)
Type 2 diabetes mellitus (T2DM) has become a growing worldwide problem of public health importance. Insulin resistance is commonly associated with obesity and a key factor mediating the progression to T2DM. The failure of ...
Novel approaches for cancer immunotherapy
(2008-05-22)
Cancer immunotherapy, i.e. activation of the patient s own immune system to combat cancer, represents a treatment strategy which is being clinically tested to complement surgery, radiotherapy and chemotherapy the current ...
Do I need a body to know who I am? Neural mechanisms of body ownership
(2011-11-07)
The feeling that our body belongs to us, and that it is an essential part of ourselves, is a fundamental aspect of human self-awareness and individual psychological identity. The intimate relation between the sense of body ...
Mechanistic studies of a novel inhibitor of the ubiquitin-proteasome system
(2019-05-03)
The ubiquitin-proteasome system (UPS) not only maintains cellular proteostasis, but plays an essential role in multiple vital cellular processes, including survival and growth. Proteasomal inhibitors, such as bortezomib, ...
Assessment of dopamine and serotonin release in the non-human primate brain using PET
(2011-01-12)
The molecular imaging technique positron emission tomography (PET) allows for non-invasive examination of biochemical markers in the living brain. For over three decades PET studies have provided important insight into the ...