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Semantic analysis of irrelevant speech in dementia
(2001-01-19)
This thesis demanded for studies within an interface between semantics, interaction and neuropsychology. The topic for the thesis was irrelevant discourse caused by dementia and foremost so called confabulation. Systematic ...
New potential targets in medulloblastoma therapy : studies on cellular mechanisms and mediators
(2010-01-15)
Medulloblastoma is an embryonal tumour that mainly affects children. It
is the most common malignant brain tumour in children and accounts for
15% of all childhood brain tumours. It most often presents in the
cerebellum ...
Novel measure of olfactory bulb function in health and disease
(2021-05-26)
Present neuroimaging techniques are capable of recording the neural activity from all over the brain but the olfactory bulb (OB). The OB is the first olfactory processing stage of the central nervous system and the site ...
Oxygen sensing in myeloid cells : implications for physiology and cancer
(2020-07-31)
All mammals depend on oxygen in order to produce life-essential energy. They acquire oxygen (O₂) through inspiration. In the lungs, O₂ is gathered by erythrocytes that consequently deliver it to all cells by the cardiovascular system. O₂ levels vary...
Epstein-Barr virus and genomic instability : a new look at the mechanisms of viral oncogenesis
(2010-12-20)
oxidative stress by transcriptional activation of the catalytic subunit of NADPH oxidise, NOX2. Stable or conditional expression of EBNA1 was associated with the accumulation of telomere abnormalities, including loss and gain of telomere signals, telomere...
Functional genomics studies of PINK1
(2007-10-25)
known risk factor for type 2 diabetes. Gene expression profiling of skeletal muscle from subjects before and after 5 weeks of inactivity by quantitative real-time PCR demonstrated a co-ordinated reduction in mitochondrial gene expression. We thus...
Inflammatory response in periodontal tissue in children with Down syndrome
(2013-05-15)
as percentage of bleeding on probing (BOP%). In all subjects, gingival crevicular fluid (GCF) was collected from six sites with paper strips, and levels of prostaglandin E2 (PGE2), leukotriene B4 (LTB4), and MMP-9 were analysed using RIA and ELISA kits. BOP...
Role of inositol pyrophosphates in pancreatic beta cell function
(2018-05-25)
, also increased IP7 levels. Silencing IP6K1, but not IP6K2, decreased glucose-mediated IP7 production and first phase insulin secretion. Therefore, IP6K1 acts as a key metabolic sensor. In diabetic ob/ob mouse islets the deranged ATP/ADP levels were...
Innate regulation of the adaptive immune system during autoimmunity
(2015-05-22)
Immune activation comprises multiple biological checkpoints to ensure proper
and regulated effector functions. Phagocytes such as macrophages, dendritic
cells and neutrophils have important functions during inflammation, ...
Plasma cell malignancies in Sweden : subgroup descriptions and regional outcomes for multiple myeloma
(2022-04-13)
Plasma cell disorders appear in various forms such as aggressive plasma cell leukemia (PCL), typical symptomatic multiple myeloma (MM), non-symptomatic smouldering multiple myeloma (SMM) and solitary plasmacytoma (SP). The ...