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Breathing and phonation : effects of lung volume and breathing behaviour on voice function
(2000-12-29)
Respiration is believed to play a central role in voice function and is thus of relevance to the clinical care of the disordered voice. The overall aim of the present study was to experimentally investigate relationships ...
Extremely preterm birth : brain imaging and outcome at early school-age
(2018-05-09)
, including all 6.5 year old children that had been born before 27 gestational weeks during three years in Stockholm for paper I and II, and in the whole of Sweden for Paper III and Paper IV- the EXPRESS (Extremely Preterm infants in Sweden Study) cohort...
CYP2C-dependent drug metabolism in vivo : influence of genetics and drug interactions
(2010-11-24)
of escitalopram (5 mg twice daily for a week), we noted a trend towards a 21% lower exposure in CYP2C19*17 homozygous individuals. However, this did not reach statistical significance in this study that was powered for a 40% difference. The clinical impact (or...
Radiomics in cancer prognosis : applications and limitations of quantitative texture analysis
(2018-11-16)
Medical imaging has become an integral part of clinical diagnostics since the discovery of X-rays at the end of the 19th century. Recent advances in computing power have opened up the possibility to extract quantitative ...
Modelling depression in animals and the potential antidepressant effect of histaminergic modulation
(2015-05-22)
Depression is at the top position for "years lived with disability" (Smith, 2014). Its aetiology
is unknown, but the pathogenesis implicates changes in glutamatergic neuronal plasticity.
Glutamatergic plasticity likely ...
Developmental origins of polycystic ovary syndrome : role of early adverse life events on adult health
(2020-03-17)
The research focus of this thesis is polycystic ovary syndrome (PCOS), the most common endocrine disorder among women of reproductive age, associated with reproductive, cardio-metabolic, and mental health complications. ...
Immediate skin-to-skin contact for very preterm and low birth weight infants : from newborn physiology to mortality reduction
(2022-05-17)
infants, and from one register study. Studies I and II involved very preterm infants in Scandinavia, where study I (n=55) investigated the effect on infant temperature at one postnatal hour and study II (n=91) infant cardiorespiratory parameters during...
Breathe (in the air) : pulmonary immunology in multiple sclerosis
(2018-02-28)
hESC, as well as being able to cluster and separate different cell types. The method implemented a masking strategy to efficiently limit capture of the highly abundant 5.8S rRNA, and incorporation of a unique molecular identifier allowed...
Hormonal regulation of HES-1 in breast cancer cells
(2008-05-21)
that exogenous expression of HES-1 causes cell cycle arrest in the G1 phase of the cell cycle. We found the cell cycle factor E2F-1, critical for G1 to S-phase progression, to be regulated by HES-1, via a cis-element in the 5 regulatory region of the E2F-1 gene...
Innate regulation of the adaptive immune system during autoimmunity
(2015-05-22)
Immune activation comprises multiple biological checkpoints to ensure proper
and regulated effector functions. Phagocytes such as macrophages, dendritic
cells and neutrophils have important functions during inflammation, ...