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Clinical and immunopathological studies in Hodgkin's disease with special reference to prognosis
(2001-02-16)
, lymphadenopathy, splenomegaly) and a malignant process with few tumour cells, T-cell accumulation and sclerosis. Today, current therapies fail to cure about 1/3 of patients with advanced HD. The main purpose of the present study has been to improve...
Inflammation and neurodegeneration in mouse nervous system : experimental application
(2006-01-26)
BL/6 mice resulted in neurodegeneration in area CA3 of hippocampus. Enhanced FAS and glial fibrillary acidic protein (GFAP) expression in hippocampus of mice was detected on day 7 after KA administration by immunohistochemistry and Western blotting...
The perspective of being a family caregiver of a patient treated for oesophageal cancer : problems and needs
(2022-03-10)
=9.2; p=0.002). Those with a higher education level had less pain (MSD=11.2; p=0.01) and better physical function (MSD=9.1; p=0.006). Regarding patient-related factors, postoperative complications were negatively associated with family caregivers...
Drug discovery targeting non-amyloid pathways in Alzheimer’s disease
(2020-04-02)
Alzheimer’s disease (AD) is the most common form of dementia with almost 50 million people affected and unfortunately, no cure or treatment to halt the disease progression is available. In the hereditary forms of AD, an ...
Genetic studies in familial non-BRCA breast cancer
(2017-11-09)
an overrepresentation of endometrial cancer in the non-BRCA families with a 6.36 % proportion (CI 4.67–8.2) compared to the proportion in the general population in the reference years 1970 (3.07 %) and 2010 (2.64 %). The main finding of the study was the strong support...
Potential mechanisms for acute health effects and lung retention of inhaled particles of different origin
(2012-05-11)
, measured lung retention was 91% at the group level. After correction for free radioactivity leaching from urine and blood samples, respectively mucociliary clearance from the central airways, the cumulative lung-particle retention was approximated to 96...
Getting in and out of shape : relevance for organ formation and cancer
(2014-09-11)
that sequester Crb3 and Par3 polarity complexes inside the cell. In human tumors from breast and colon cancer patient’s p60 AmotL2 expression correlates with loss of tissue architecture and cell polarity. Furthermore we provide data showing that p60 AmotL2 acts...
Studies on novel interactors in human adipose tissue
(2011-05-19)
Obesity is associated with a mild inflammation and altered protein secretion in adipose tissue. These changes have been suggested to contribute to the development of obesity-associated disorders including, insulin resistance, ...
Oxygen sensing in myeloid cells : implications for physiology and cancer
(2020-07-31)
All mammals depend on oxygen in order to produce life-essential energy. They acquire oxygen (O₂) through inspiration. In the lungs, O₂ is gathered by erythrocytes that consequently deliver it to all cells by the cardiovascular ...
Determination of transcription factor binding specificities
(2015-11-19)
The term "genetic code" refers to the way in which the information encoded in nucleic acids
is converted into the amino-acid sequence of proteins. There is however also a second genetic
code, one that is used by the cells ...