Search
Now showing items 1-10 of 16
Chromatin remodelling and gene regulation
(2001-04-06)
Chromatin plays an important role in gene regulation, as it forms an obstacle for a number of proteins that need access to the DNA. Several protein complexes that open up the chromatin structure have been identified and ...
Genetic and biochemical characterization of a novel sensor of extracellular amino acids in yeast
(2001-01-26)
and compartmentalization of amino acids led to the isolation of a unique member of the amino acid permease family, SSY1, and two additional components PTR3 and SSY5. Ssy1p has a unique, extended N-terminal domain that is not present in other amino acid permeases. Ssy5p...
T cell mediated immunity in malaria and mycobacterial infection : a protective role for gd+ T cells
(2000-12-22)
T cell mediated immunity is essential against intracellular infections. Studies of cell mediated immunity are important for the optimal design and development of effective vaccines. Identifying correlates of protective ...
Factors influencing the turnover of olfactory receptor neurons
(2000-12-29)
The olfactory system has a striking capacity for neuronal plasticity throughout life and the olfactory epithelium is able to generate both neuronal and non-neuronal cells in the normal adult animal as well as after ...
Molecular diversity in the Notch receptor family
(2001-05-18)
. CADASIL is caused by missense mutations in the human Notch3 gene. The mutations always affect cysteine residues located in the extracellular domain of the Notch3 receptor. There is currently no biochemical data available on the mechanism by which...
Vocational rehabilitation of unemployed sick-listed people in a Swedish rural area : an individual-level study based on social insurance data
(2000-11-28)
The long trend of low unemployment and increasing economic growth in Sweden was broken in the early 1990 s. In a short time, the rate of unemployment had risen from 1.3% in 1990 to 8.2% in 1993. A previous study made in Stockholm showed that among...
Molecular endocrinology of target enzymes in androgen metabolism : implications for prostate cancer
(2001-03-02)
Genes that are responsible for variations in drug and hormonal responses
are sometimes also associated with the pathophysiology of diseases.
Understanding the aetiology of a disease is often essential for the
design of ...
Preeclampsia and other circulatory diseases during pregnancy : etiological aspects and impact on female offspring
(2001-03-01)
The aims of this thesis were to investigate and compare environmental effects on the liability of developing preeclampsia and gestational hypertension; to estimate the relative importance of genetic and environmental effects ...
Regulation of virulence gene expression in Staphylococcus aureus
(2000-11-24)
The pathogenic bacterium Staphylococcus aureus has the ability to cause a wide variety of human diseases, ranging from superficial abscesses and wound infections to deep and systemic infections such as osteomyelitis, ...
Pharmacological and hormonal effects on bone with emphasis on osteoporosis : experimental studies in the rat
(2001-02-23)
In this thesis influences of some hormones (17beta-estradiol and human
parathyroid hormone) and drugs (risedronate and verapamil) on bone were
investigated.
The effects of verapamil, a phenylalkylamine calcium ...