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Chemical and mass spectrometrical methods in protein analysis
(2000-11-24)
Sensitive analytical methods are essential in protein studies because of frequently encountered limited sample availability. There is a constant need for optimization of sample preparation and analytical procedures for ...
Oxygen sensing in myeloid cells : implications for physiology and cancer
(2020-07-31)
All mammals depend on oxygen in order to produce life-essential energy. They acquire oxygen (O₂) through inspiration. In the lungs, O₂ is gathered by erythrocytes that consequently deliver it to all cells by the cardiovascular ...
Oxygen-dependent regulation of HIF-1alpha expression and function
(2009-09-04)
Hypoxia is a state of reduced oxygen levels below normal values. It occurs in the pathophysiology of many diseases and plays important roles in mammalian physiology and development. The hypoxia-inducible factors (HIFs) are ...
Regulation of skeletal muscle metabolism and development by small, non-coding RNAs : implications for insulin resistance and type 2 diabetes mellitus
(2018-05-23)
microRNAs (miRNAs) are a class of epigenetic post-transcriptional regulators. These short (~22 nucleotides) non-coding RNAs can potently reduce protein abundance through direction of the RNA-induced silencing complex to ...
To cut or not to cut? Episiotomy in vacuum extraction
(2022-04-05)
BACKGROUND AND AIMS: Obstetric anal sphincter injury (OASIS) may cause anal incontinence, as well as sexual dysfunction and psychological trauma. Mediolateral and lateral episiotomy have been shown to be protective against ...
Person-centered shift handovers in oncological inpatient care
(2019-01-31)
Surveys show that patients are not sufficiently involved in decisions and planning regarding their own care, and patients have reported unfulfilled information needs in inpatient settings. To develop inpatient cancer care ...
Adaptive immunity in urothelial cancer : molecular and clinical aspects
(2018-10-05)
In the battle between the immune system and cancer, tolerance mechanisms otherwise protective against autoimmunity, are exploited to halt the anti-tumor immune response. In this model, tumors turn distinct parts of the ...
Pathogenic mechanisms behind dysregulated angiogenesis with focus on HIF and IGF-I signaling
(2013-09-12)
Angiogenesis is a complexly regulated process activated to assure cells with normal supplies of nutrients and oxygen. Playing such an essential role in the homeostasis of tissues, it is critical to understand its physiology ...
Biomarkers and psychological stress in amyotrophic lateral sclerosis
(2023-04-05)
Amyotrophic lateral sclerosis (ALS) is a complex and progressive neurological disorder that causes a wide range of symptoms, including muscle weakness, mobility impairment, and marked functional decline. Unfortunately, ...
Prognosis and progression in chronic kidney disease
(2010-09-17)
Chronic kidney disease (CKD) is a life threatening condition with high
risk of pre-term death and need for dialysis. The population prevalence
of CKD has been estimated to 10-13% for both Europe and the USA. We
investigated ...