Search
Now showing items 1-6 of 6
Biochemical characterisation and clinical correlation of neuropeptides in neuroblastoma with emphasis on neuropeptide Y
(2000-10-27)
spectrometry, intact NPY(1-36) and the metabolic fragments NPY(3-36) and NPY(31-36) were isolated and identified in neuroblastoma tumour tissue. The identification of these fragments shows that NPY processing in vivo generates NPY-metabolites known to have...
Wnt/beta-catenin signaling in midbrain dopaminergic neurons
(2006-04-07)
Parkinson's disease (PD) is caused by a progressive degeneration of the dopaminergic (DA) neurons of the substantia nigra. However, the mechanisms underlying the degeneration remain elusive and there is no cure for P1) at present. Cell replacement...
RNA polymerase I inhibition : mechanism and exploitation in cancer treatment
(2022-10-10)
Cancer is an umbrella term for diseases characterized by uncontrollably proliferating abnormal cells that often have also gained the ability to spread and invade other tissues. It is one of the leading causes of death ...
Immunoglobulin gene usage and affinity maturation in antiviral antibodies
(2023-04-18)
infected healthcare workers and evaluated the neutralization activity of germline-reverted and allele-swapped S-specific IGHV1-69*20-using antibodies from two independent donors carrying this allele. Neutralization was retained when reverting the IGHV...
Mechanistic studies of a novel inhibitor of the ubiquitin-proteasome system
(2019-05-03)
The ubiquitin-proteasome system (UPS) not only maintains cellular proteostasis, but plays an essential role in multiple vital cellular processes, including survival and growth. Proteasomal inhibitors, such as bortezomib, ...
Identification of novel modulators of protein synthesis and nucleolar biology using high throughput phenotypic screens
(2022-02-23)
(Bromosporine-1 and PFI-1) and sodium phenylbutyrate (Na-Phen), currently in clinical trials, as modifiers of PR20 toxicity in different cell lines and in developing zebrafish embryos. Our work shows that BET Bromodomain inhibitors rescue the nucleolar stress...