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Early airway inflammation in allergic asthma : aspects of pulmonary innate immunity
(2000-10-20)
Allergic asthma is a chronic disease in which allergen-induced inflammatory processes of the airways contribute to the development of symptoms and eventually may lead to remodeling of the airway tissue. In the present work ...
Predicting and monitoring disease course in rheumatoid arthritis : imaging, biomarkers, risk factors, and integrative medicine
(2017-04-28)
Rheumatoid arthritis (RA), the most common inflammatory arthritis, is a chronic, potentially debilitating autoimmune disease that can lead to functional disability, bone erosion, and chronic pain. The modern era of treatment ...
The role of the DAMP molecule HMGB1 in neuroinflammation and macrophage activation
(2021-10-22)
High mobility group box 1 (HMGB1) is a highly conserved nuclear protein expressed in all eukaryotic cells. While its nuclear functions are vital, we know today that HMGB1 also functions as a Damage Associated Molecular ...
Cardiovascular development of the preterm infant
(2016-09-16)
The numbers of preterm births and cardiovascular deaths are increasing in most countries. The causes of both developments are multiple and apparently not related to each other. However, preterm birth might provide an ...
Cost analysis and policy implications in psychiatric care
(2009-04-01)
in Sweden in 2001 (Study I) was estimated at MSEK 85 774 (M€ 9 426, €1= SEK9.1). Indirect costs were totally predominant and constituted about 80% of the total cost, i.e. production losses due to early retirement, sickness absence and premature death...
Antiretroviral treatment outcome and molecular epidemiology of HIV-1 subtype C drug resistance in Ethiopia
(2018-08-06)
determined the rate of treatment failure at month 6 and 12. Four multivariable logistic regression models were developed to identify baseline predictors of treatment outcome. OT analysis identified treatment failure in 8% and 7%, whereas with ITT analysis...
Too much, too late? Drug prescribing for older people near the end of life
(2019-08-28)
continued to receive preventive drugs until the very end of life. Over the course of the last 12 months of life, there was little change in the receipt of antihypertensive agents (absolute change -0.3%, 95% CI -0.6 to 0.0), vitamin K antagonists (+1.5%, 95...