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The cell cycle regulators p15, p16, p18 and p19 : functions and regulation during normal cell cycle and in multistep carcinogenesis
(2000-09-29)
The tumor suppressor protein p16INK4a and its family members p15INK4b, p18INK4c and p19INK4d (the INK4 proteins) inhibit the cyclin-dependent kinases CDK4 and CDK6, which are key regulators of the retinoblastoma protein (pRb). pRb guars entry...
The perspective of being a family caregiver of a patient treated for oesophageal cancer : problems and needs
(2022-03-10)
=9.2; p=0.002). Those with a higher education level had less pain (MSD=11.2; p=0.01) and better physical function (MSD=9.1; p=0.006). Regarding patient-related factors, postoperative complications were negatively associated with family caregivers...
Molecular studies of prognostic and etiological factors in childhood leukemia
(2015-04-29)
Acute lymphoblastic leukemia (ALL) is the most common cancer in childhood. It is caused
by the somatic acquisition of genetic abnormalities and malignant transformation of
immature lymphocytes in the bone marrow, most ...
In vivo functions of mammalian glutaredoxin 2
(2008-08-29)
Oxygen is essential for all respirating life forms. However, the use of molecular oxygen as terminal electron acceptor of the respiratory electron chain leads to the generation of reactive oxygen species (ROS) as product ...
Rheumatoid arthritis as a modifier of periodontitis
(2007-01-19)
Periodontitis is a chronic tissue-destructive condition in which the
tooth-supporting collagen fibers of ligament and bone are broken down
mainly by the host s overreactive immune inflammatory response. The
relation between ...
Hormonal regulation of HES-1 in breast cancer cells
(2008-05-21)
Hairy and Enhancer of Split homolog 1 (HES-1) is a transcriptional repressor belonging to the basic helix-loop-helix family of proteins, and has been shown to have a pivotal role as a regulator of neurogenesis, myogenesis ...
Social influences on affective responses to negative experiences
(2023-01-25)
As social human beings, the way we emotionally respond to what happens around us is often regulated by our interactions with others. The overall aim of this thesis is to advance the understanding of how social influences ...
Brain imaging in extremely preterm infants : relations to perinatal factors and outcome
(2014-01-03)
The survival of extremely preterm infants has improved over the last decades along with the advances in perinatal care. These immature children are born at a vulnerable stage of brain development, before entering the third ...
Nucleic acid in gene delivery and gene regulation
(2011-08-01)
The concept of gene therapy, initially attributed to a technology that would allow the correction of inherited genetic disease, has evolved over the years. The realization of the immense technical hurdles to achieve genetic ...
Genetic and epigenetic factors shaping the transcriptome in multiple sclerosis and its animal model
(2014-11-21)
Multiple Sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system. Susceptibility to develop MS is determined by both genetic and environmental factors. The epigenome resides in the ...