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Genetic analysis of neurofibromatosis type 2 (NF2) patients and NF2-associated tumors with emphasis on chromosome 22 deletions
(2000-09-15)
Neurofibromatosis type 2 (NF2) is an autosomal dominant disease with the hallmark of bilateral vestibular schwannomas. NF2 patients may also develop schwannomas at other locations as well as meningiomas, neurofibromas and ependymomas. NF2 shows a...
Socially dependent avoidance learning : mechanisms of adaptive behavior
(2014-08-08)
Many aspects of human social behavior are likely to be shaped by punishment, threats of punishment, and avoidance of punishment. However, surprisingly little is known about the psychological mechanisms underpinning these ...
Getting in and out of shape : relevance for organ formation and cancer
(2014-09-11)
that angiomotin-like 2 is expressed as two isoforms with distinct functions. The longer isoform p100 AmotL2 is localized to cell-cell junctions, and associates to the VE-cadherin complex where it couples adherent junctions to contractile actin fibers. Using gene...
Aspects of arterial wall healing : re-endothelialization, intimal hyperplasia and vascular remodeling
(2019-05-08)
Cardiovascular disease is the leading cause of mortality in the world. Despite prevention, the need for interventions remains high. Patients with type 2 diabetes mellitus have an increased cardiovascular burden and are at higher risk...
Tissue biomarkers in prostate cancer
(2009-09-25)
Prostate cancer (PC) is the most common male cancer in the western world. Better biomarkers are needed to support diagnosis, prediction of prognosis and treatment decision Radical prostatectomy (RP) specimens are routinely ...
Regulation of protein synthesis in human skeletal muscle : separate and combined effects of exercise and amino acids
(2014-05-22)
Skeletal muscle is a highly plastic tissue which has the ability to adapt to various forms of external stimuli such as diverse modes of contractile activity. Thus, performance of endurance exercise over several of weeks ...
The influence of sex hormones on neuromuscular function and premenstrual symptoms
(2017-04-13)
The menstrual cycle with fluctuation in female sex hormones has been suggested to influence neuromuscular function. However, variation in ligament laxity, soft tissue stiffness, and skeletal muscle strength across the ...
Growth and morbidity in extreme preterm born infants
(2013-05-17)
showed that the most pronounced CU growth in both Wt and Ht occurred during the first year after FT age; followed by a plateau between 1 and 2 years but with more pronounced Wt than Ht development, a trend that continued until 10 years. Children...
Identification of novel modulators of protein synthesis and nucleolar biology using high throughput phenotypic screens
(2022-02-23)
repeats (DPRs). ALS is a fatal neurodegenerative disease characterized by loss of upper and lower motor neurons, leading to muscular paralysis and death, within 3 to 5 years after diagnosis. The expansion of G4C2 repeats within the first intron of the C9...
Clinical studies on drug treatment of hospitalised patients : general infectious diseases and acute myocardial infarction
(2013-05-03)
. We found that CYP2D6 is a major factor of metoprolol disposition and effects in AMI patients and also a major determinant of individual variability of response to the treatment. Common exogenous medications prescribed for treatment of depression...