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Development of new NMR techniques and structural characterization of complexes between the N-terminal domain of the E. coli arginine repressor and operator DNA
(2000-09-15)
This thesis includes the development of new solution NMR methods for the study of biomolecules and the characterization of complexes between the N-terminal domain of the E. coli arginine repressor (ArgR-N) and operator ...
Mechanisms of adaptation to the fitness cost of antibiotic resistance
(2007-05-18)
The dissemination and persistence of antibiotic resistance, is not only
depending on the volume of drugs used but also on the resistance
mechanisms effect of bacterial fitness (reproductive ability). Fitness is
a multifactorial ...
Pathophysiology in postterm pregnancy : epidemiology, risk factors and cervical ripening
(2012-05-07)
with real-time PCR (RT-PCR). Immunohistochemistry was performed to analyze expression and distribution of cytokines (IL- 1β, IL-6, IL-8, IL-10 and IL-18), prostaglandin receptors (EP1-4 and FP) and stroma factors (CTGF, calgranulin B, furin and ALOX 15...
The role of socio-emotional factors for cognitive health in later life
(2016-10-07)
studies based on the Cardiovascular Risk Factor, Ageing and Dementia (CAIDE) Study, a population based cohort study on 1511 persons in eastern Finland, who at baseline were 50.4 years. Two re-examinations have been performed in the CAIDE Study, in 1998...
Identification of novel modulators of protein synthesis and nucleolar biology using high throughput phenotypic screens
(2022-02-23)
repeats (DPRs). ALS is a fatal neurodegenerative disease characterized by loss of upper and lower motor neurons, leading to muscular paralysis and death, within 3 to 5 years after diagnosis. The expansion of G4C2 repeats within the first intron of the C9...
Educational inclusion for students with neurodevelopmental conditions
(2022-05-20)
Introduction: Inclusive education is the response to the human rights movement that requested equal rights to general education for all students, independent of their prerequisites and/or disabilities. Inclusion is different ...