Search
Now showing items 1-9 of 9
Trophic factors, neuroprotection and spinal cord repair
(2000-09-01)
[alpha]-1, 2, 3, 4 and the proto oncogene RET.
Another trophic factor studied in the present thesis, VEGF, is best known to act on endothelial cells in blood vessels. VEGF may signal by binding to Flk-1, Flt-1 or neuropilins. Attempts to repair injured...
The TRIM21/Ro52 E3 ligase and its antibodies in autoimmune disease
(2010-11-11)
/Ro52 protein itself has remained unknown until its recent description as a tripartite-motif (TRIM) family member and an E3 ligase involved in ubiquitination. Congenital heart block (CHB) is a passively acquired autoimmune condition that may develop...
Factors affecting growth, differentiation and apoptosis of osteoblastic and osteosarcoma cells
(2008-10-17)
, inhibited adipocyte formation and enhanced osteoblast differentiation, while the inhibitor NAM had the opposite effect. In the second paper, osteoblastic cells from different origins, mouse, rat, and human, were treated with 1alpha,25(OH)2D3 and its analogue...
New molecular tools for prenatal diagnosis
(2016-10-04)
to fill in a questionnaire at nine maternity clinics located in different areas of Stockholm. The overwhelming majority of the women (91%) considered examinations aiming to detect fetal abnormalities to be good. Regarding NIPT, 60% stated that they had...
Pharmacological and hormonal effects on bone with emphasis on osteoporosis : experimental studies in the rat
(2001-02-23)
In this thesis influences of some hormones (17beta-estradiol and human
parathyroid hormone) and drugs (risedronate and verapamil) on bone were
investigated.
The effects of verapamil, a phenylalkylamine calcium ...
PAK4 signaling in development and cancer
(2019-10-17)
Our understanding of cancer biology has been evolving rapidly shaped by groundbreaking discoveries. We now understand that cancer is not one disease but many, and that tumors are not foreign objects in the human body but ...
Exploring immunotherapeutic targets in the tumor microenvironment
(2015-11-19)
The immune system has developed along with the evolution of increasingly complex
cellular organisms to sustain homeostasis and protect from threats. Cancer, a detrimental
side effect of increasing organismic complexity, ...
Notch signaling requiem : orchestral role of notch signaling in cancer and developmental disease
(2020-08-14)
the extent of Notch2 and Notch3 activation. Lacrymosa: In Paper V, we observed that hyperactive Notch in the luminal lineage during lactation cause defect in ductal development and led to mammary tumour development. Furthermore, we showed that this lineage...
Exploring the role of vitamin E in Alzheimer’s disease : an epidemiological and clinical perspective
(2012-05-10)
Vitamin E, the main non-enzymatic lipophylic antioxidant in the human body, has a major role in protecting the brain from damage mediated by free radicals. The term vitamin E encompasses eight natural congeners (forms): ...