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Immunologic and genetic studies of rat adjuvant-induced arthritis
(2000-09-28)
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with a multifactorial and largely unknown etiology. It is influenced by both environmental and genetic factors, and understanding of disease mechanisms and ...
Human papillomavirus infection, genetic instability and invasive properties of cervical lesions
(1999-08-27)
Cancer of the uterine cervix is one of the most frequent malignancies in women worldwide. Approximately half a million new cases of cervical cancer are diagnosed each year, and about 200 000 women die from the disease. ...
To cut or not to cut? Episiotomy in vacuum extraction
(2022-04-05)
). After statistical balancing using propensity score, episiotomy was associated with a reduction in OASIS from 15.5% to 11.8%, ie an average treatment effect -3.7% (95% CI -4.3 to -3.0). The numbers needed to treat (NNT) to prevent one OASIS was 27...
A 10-year follow-up of people with multiple sclerosis-aspects of disability and health, use of and satisfaction with care, and feasibility of cognitive behavioural therapy
(2014-11-21)
Background: Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease in the central nervous system which affects a number of life areas of the afflicted individual. Detailed knowledge is required on ...
Pathophysiological characterization of traumatic brain injury using novel analytical methods
(2023-05-02)
Severity of traumatic brain injury is usually classified by Glasgow coma scale (GCS) as “mild”, "moderate" or "severe’, which does not capture the heterogeneity of the disease. According to current guidelines, intracranial ...
Estimation of gestational age by ultrasound and extreme prematurity
(2012-05-16)
Accurate estimation of the gestational age of the fetus is a key assessment made by providers of obstetric care during pregnancy, since decisions concerning management strategies are dependent on this estimate. Thus, the ...
Vascular and inflammatory markers in chronic kidney disease
(2015-03-27)
In patients with chronic kidney disease (CKD), inflammation and malnutrition are harmful and highly prevalent conditions with influence on the atherosclerotic process and outcome. The risk of cardiovascular disease (CVD) ...
Pediatric acute neuropsychiatric syndrome : diagnosis, biomarkers and treatment
(2019-05-23)
Background: Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) and Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) are proposed diagnoses combining a clinical picture ...
Gene environment-interaction and cardiovascular phenotype in obesity and diabetes
(2019-02-22)
Although a large body of evidence supports the notion that genes determine cardio-metabolic traits and outcomes, the non-genetic regulation of these events has recently gained increasing attention. Plastic chemical ...
Structural studies of lumazine synthases : thermostability, catalytic mechanism and molecular assembly
(2005-12-27)
Riboflavin, also known as vitamin B2, is biosynthesized in plants, bacteria, archaea and fungi. The primary biological function of riboflavin is related to its existence as a component of the two coenzymes, flavin ...