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Exercise effects on the mitogen-activated protein (MAP) kinase cascade in skeletal muscle
(2000-11-03)
was assessed. ERK1/2 and p38 MAP kinase phosphorylation was increased 1.6- and 2.3-fold, respectively by contractions, with no change in ERK1/2 and p38 MAP kinase protein expression. ERK1/2 displayed a fiber-type specific pattern of protein expression...
New evidence on germ-cell testicular cancer aetiology
(2004-01-09)
evaluated recent trends in testicular cancer incidence in Northern European countries.
Using data from birth records and from the Swedish Cancer Register, we carried out a casecontrol study of 628 cases and 2,309 controls. We aimed at investigating...
Neural correlates of individual differences in personality and intelligence : studies using an isochronous timing task and voxel based morphometry
(2009-01-14)
It is easy to imagine that humans have always noticed the differences
between themselves and others and perhaps even speculated about the
origins of these differences. The study of individual differences as a
formal ...
Breast cancer natural history models and risk prediction in mammography screening cohorts
(2022-03-31)
In this thesis, the foundations are laid for a new natural history model for breast cancer—specifically designed to take advantage of detailed screening cohorts. Three diverse applications of this model are then presented. ...
Factors affecting growth, differentiation and apoptosis of osteoblastic and osteosarcoma cells
(2008-10-17)
, inhibited adipocyte formation and enhanced osteoblast differentiation, while the inhibitor NAM had the opposite effect. In the second paper, osteoblastic cells from different origins, mouse, rat, and human, were treated with 1alpha,25(OH)2D3 and its analogue...
Diabetic osteopathy : a study in the rat
(2012-03-09)
The present study on non-obese Goto-Kakizaki (GK) rats with type-2 diabetes and neuropathy was an attempt to describe and define pertinent features of diabetic osteopathy. Altogether, the study included 33 GK rats aged 12 and 20 months, and 36 age...
Transition-aged autistic youth : functioning, quality of life, and internet-delivered psychoeducation
(2023-08-21)
participants, aged 16-25 years, to be randomised according to 2:1:1 to SCOPE, self-study online of informative autism websites, or treatment as usual (TAU). The primary outcome of autism knowledge, and the secondary outcomes of symptoms of mental ill-health, Qo...
Natural killer cells in cancer : studies on migration and cytotoxicity
(2014-05-08)
to NKG2D-mediated lysis due to high expression of ULBP2 on tumor cells. In addition, tumor cells produced high levels of CXCL10 which attracted CXCR3-positive NK cells in vitro. In ATC tumor samples we found a suppressed NK cell population although...
What can genetically informative designs add to the understanding of ADHD?
(2016-02-23)
Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent and clinically
heterogeneous neurodevelopmental disorder affecting approximately 3.4–7.3% children and
adolescents and 2.5–3.4% adults worldwide, ...
Hereditary factors in endometrial cancer
(2015-02-03)
of cases occur in women older than age 50. About 2% of EC may have a familial association related to Lynch syndrome (LS). About 80% of women with Cowden syndrome have the PTEN mutation, which increases their lifetime risk of developing EC. The benefit of EC...