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Elderly disabled persons in the home setting : aspects of activities in daily life
(2000-08-11)
The overall aim of this thesis was to explore and describe elderly disabled persons' activities in daily life in the home environment from an occupational perspective and, secondly to describe occupational therapy interventions ...
Linking innate and adaptive immunity to streptococcus pneumoniae
(2012-09-05)
Streptococcus pneumoniae (the pneumococcus) most commonly colonizes the human nasopharyngeal mucosa without causing any symptoms. However, this organism has the potential to spread to normally sterile sites and cause ...
Genetic characterization of patients with frontotemporal dementia and amyotrophic lateral sclerosis in the Nordic countries
(2012-05-21)
. The mutation frequency of TARDBP in Nordic ALS patient was 1.7 %. Furthermore, the p.Arg361Thr was shown to be present in a family with both ALS and FTD-ALS which further strengthens the connection between FTD and ALS....
Role of IL-7 in immune activation during HIV-1 infection
(2011-08-02)
of peripheral NK cell subsets and functionality of CD28- T cells and 2) the impact of the lymphopenia-associated cytokine IL-7 in promoting immune activation via its priming role for T cells proliferation and its indirect effects on B cells and NK cells...
Genetic studies of glomerulonephritis with special focus on IgA nephropathy and Lupus nephritis
(2010-11-25)
IgA nephropathy and nephritis in Systemic Lupus Erythematosus (SLE) are two common forms of glomerulonephritis with unknown etiology. As for many other complex diseases, both genetic and environmental factors could be of ...
Oncologic and functional outcomes after robot-assisted radical hysterectomy for cervical cancer
(2020-10-16)
Background: Cervical cancer is the fourth most common cancer in women worldwide, but the incidence has rapidly declined in developed countries after the introduction of structured screening programs. This disease is caused ...
Role of p70 S6 kinase in the formation of tau pathologies in Alzheimer’s disease
(2005-08-10)
One of the important neuropathological features of Alzheimer's disease (AD) is the tau pathology seen as accumulation and hyperphosphorylation of this protein. Evidences showed that tau could be phosphorylated mostly at ...
Tissue biomarkers in prostate cancer
(2009-09-25)
Prostate cancer (PC) is the most common male cancer in the western world. Better biomarkers are needed to support diagnosis, prediction of prognosis and treatment decision Radical prostatectomy (RP) specimens are routinely ...
Unraveling the role of NOTCH3 dysfunction in disease and for therapy development : a focus on CADASIL
(2021-08-20)
The Notch signaling pathway, including the Notch3 receptor, is involved in many pivotal contexts of cell signaling and cell fate determination processes during development and in adulthood. Different mutations in the NOTCH3 ...
Factors associated with lung function impairment in children and adults with obstructive lung disease
(2008-05-14)
Obstructive lung diseases are a group of diseases in which there is a limitation in the flow of air into or out of the lungs. Two common such diseases are asthma, which is found in both children and adults, and chronic ...