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A pharmacokinetic and pharmacodynamic study of an antiepileptic drug (lamotrigine) in young patients with drug-resistant generalized epilepsy
(2000-05-05)
The purpose of the present study was to investigate the safety and efficacy of lamotrigine in young patients with drug-resistant generalised epilepsy. This group of patients is difficult to study due to a high seizure ...
Extra- and intracellular electronic conductance of signals and its significance for synaptic plasticity
(2008-08-08)
Electrical signals play a pivotal role in the normal function of most if
not all organisms. Understanding the electrophysiological principles that
govern electrical signaling is essential for insights into normal- ...
Guinea pig osteoarthrosis : morphological and biochemical studies
(1999-02-04)
Hartley guinea pigs spontaneously and reproducibly develop an arthropathy mimicking human primary osteoarthrosis. The morphological lesions first appear between 6 and 12 months of age, when it is confined to the non-meniscus-covered central...
Clinical studies of glucose variability and hypoglycemia in adult patients with type 1 diabetes
(2011-11-02)
.05). The prevalence of SH had increased from 17% to 27% (p<0.05) and there was a slight decrease in HbA1c, 7.6% to 7.4% (p<0.05). In spite of the more frequent use of multiple injection therapy and more frequent SMBG, the prevalence of SH increased by more than 50...
Optimising treatment outcomes in people living with systemic lupus erythematosus
(2022-11-11)
the LLDAS (8.6%) but less frequent than SRI-4 (45.1%) and yielded the strongest correlation with the physician’s global assessment (PGA) compound in remission definitions (PGA<0.5; rφ=0.36, P<0.001). Our findings indicated that a definition based on one...
Generation and investigation of neural microenvironment in health and disease
(2019-10-09)
Cells in our body are under the constant influence of intrinsic and extrinsic factors that modulate their behavior. Early on, starting during the development of the organism, growth factors, nutrients, oxygen, the extracellular ...
Diagnosis and treatment of Helicobacter pylori infection in Vietnamese children
(2009-11-20)
strains). Twice-daily dosage was more effective for eradication of clarithromycin resistant strains than once-daily dosage (OR 6.92, 95% CI 1.49-32.13, relative to once-daily dose). Factual antibiotic dose per kilo bodyweight were significantly associated...
Ultrasound and fluorescence optical imaging biomarkers for early diagnosis and prediction of rheumatoid arthritis
(2023-01-12)
-inflammatory biomarkers in predicting arthritis onset in individuals positive for Anti-CCP with musculoskeletal complaints at risk of RA development. We propose the recognition of a high-risk RA phase characterized by presence of certain ACPA reactivities, IL15-Rα, IL6...
Aspects of arterial wall healing : re-endothelialization, intimal hyperplasia and vascular remodeling
(2019-05-08)
for validation and identification of novel treatment targets. The utilization of transcriptomic data to identify new biological pathways in the arterial wall healing process can be exemplified with proprotein convertase subtilisin/kexin 6 (PCSK6). Previously, we...
Molecular and epidemiological investigations of lung involvement in very early rheumatoid arthritis
(2015-11-26)
of ACPA-positive patients. Using mass spectrometry we were able to identify two novel citrullinated vimentin peptides that were present in a majority of bronchial (n=6) and RA synovial biopsies (n=7) tested. Immune reactivity against these targets...