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Hsp70 in immunotherapy : a potential vector in cancer and viral vaccines
(2000-04-28)
New efficient vaccines against cancers and infectious diseases are in demand. In 1993 heat shock protein 70 (hsp70) purified from tumour was shown to elicit tumour protection in mice. It was also shown that the protection ...
Gestational age and size at birth and risk of esophageal inflammation and cancer
(2013-01-21)
(OR 2.7, 95% CI 2.2-3.5 and OR 1.5, 95% CI 1.3-1.7, respectively), and even more so among those diagnosed before 10 years of age (OR 6.8, 95% CI 4.7-10.0 and OR 2.0, 95% CI 1.6-2.5, respectively). We found an increased risk of being diagnosed...
Bone marrow mesenchymal stem and progenitor cells in myeloid malignancies
(2017-10-24)
, and matrix proteins. Dynamic BM niche cell analysis and gene expression assay revealed that the BM niche alterations correlated with AML burden. We next functionally determined the roles of BM MSCs marked by Ebf2 expression in AML progression. We demonstrated...
Trajectory mapping of human embryonic stem cell cardiogenesis reveals lineage branch points and an ISL1 progenitor-derived cardiac fibroblast lineage
(2021-02-17)
A family of multipotent heart progenitors plays a central role in the generation of diverse myogenic and nonmyogenic lineages in the heart. Cardiac progenitors in particular play a significant role in lineages involved in ...
Dynamics of proteinopathies in Alzheimer’s disease as measured by PET and CSF biomarkers
(2018-10-05)
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the extracellular aggregation of the amyloid-β (Aβ; amyloid) peptide and the intraneuronal accumulation of the protein tau. Independently, and in ...
The role of proprotein convertases in vascular disease
(2022-10-18)
-time to reach the peak at day 5 after injury. Based on microarray analysis, we uncovered positive correlations on day 5 after injury between Pcsk6 and matrix metalloproteases Mmp2 and Mmp14. Neointima formation in response to carotid artery ligation was found...