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Influence of antipsychotic drugs on hormone levels
(2000-11-17)
The aim of the studies summarized in this thesis was to investigate the influence of antipsychotic drugs on hormone levels, in order to identify causes of hormonally related side effects of these drugs. The effect of ...
Recurrent abdominal pain in children : the concept, aetiology, diagnostics and prognosis
(2018-08-10)
. In study I, 258 children 4-17 years old seeking care for gastrointestinal complaints were evaluated. Validated Rome III based patient-administered symptom questionnaires were filled in at the initial visit, blinded to the clinician. One year after inclusion...
Factors associated with lung function impairment in children and adults with obstructive lung disease
(2008-05-14)
function at age 4 and 8 years in a birth cohort of 4,000 children and found that asthma symptom onset in the first 4 years of life was, on a group level, associated with impaired exhaled flows. This was found irrespective of the persistence of symptoms...
Long-term exposure to air pollution from road traffic and development of airway and allergic diseases in children
(2012-11-22)
of <10 μm (PM10) from traffic, were assigned to residential, day care, and school addresses by dispersion models. Air pollution exposure during the first year of life was related to an increased risk of sensitization to pollen allergens at 4 years (OR, 1...
Severe asthma and asthma control in schoolchildren
(2013-02-07)
. 34%, p < 0.001) at 12 years. Severe asthma was prevalent in 0.4% of children in a normal urban population at age 12, or 4% among children with asthma. Children with impaired asthma control at both 8 and 12 years in the BAMSE cohort (n = 91...
MHC-class I restricted peptide-based immunomodulation of CD8+ T and NK cells
(2012-09-06)
The main aims of the immune system are to protect the host from potential threats by distinguishing self from non-self and altered-self. T cells and NK cells play a key role in the identification and elimination of threats ...
Studies on ribonucleotide reductase, a target for anticancer therapy, with focus on electron donor aspects : thioredoxin and glutaredoxin systems
(2009-03-27)
Faithful replication of DNA and its repair are fundamental processes in
all living cells which utilize deoxyribonucleotides as DNA building
blocks. Ribonucleotide reductase (RNR) is the essential enzyme for de
novo ...
To cut or not to cut? Episiotomy in vacuum extraction
(2022-04-05)
). After statistical balancing using propensity score, episiotomy was associated with a reduction in OASIS from 15.5% to 11.8%, ie an average treatment effect -3.7% (95% CI -4.3 to -3.0). The numbers needed to treat (NNT) to prevent one OASIS was 27...
Notch in cancer and cancer metabolism : six degrees of intracellular turbulence
(2016-08-12)
Notch signaling is an evolutionarily conserved cell-to-cell contact-dependent signaling mechanism in multicellular organisms directing cellular fates both in early development and adult tissues. In metazoans the Notch ...
Functional characterization of cytosolic and mitochondrial thioredoxin reductases
(2006-09-15)
Mammalian thioredoxin reductases (TrxRs) are homodimeric selenoproteins belonging to the nucleotide oxidoreductase family. They contain a C-terminal penultimate selenocysteine residue, which is kept reduced by the N-terminal ...