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Factors related to the occurrence of gastric adenocarcinoma subtypes
(2000-04-07)
with differing gastric cancer incidence. We identified all new cases of gastric adenocarcinoma in the study area, with a completeness of case ascertainment exceeding that of the Swedish Cancer Register (papers I and II). All Swedes aged 40-79, living in the two...
Development of squamous cell carcinoma in venous ulcers
(2000-04-14)
Apart from numerous case reports, studies on the epidemiology and the outcome of malignant transformation in venous leg ulcers are scarce. Even the aetiology is unsettled, and the genetic effects of the chronic ulcer state ...
Fecal immunochemical test in colorectal cancer screening : impact of screening strategy and gender on colonoscopy findings, missed lesions and costs
(2022-03-18)
%) had FIT level of 40-79μg/g and would thus have remained undetected at cut-off level 80μg/g in both genders. The gender-specific screening strategy was estimated to be 16% more expensive than the gender-equal strategy, corresponding to a 3% increment...
When systemic lupus erythematosus (SLE) involves pain : occurrence and impact on daily life
(2018-11-19)
completed again at year 7, when 64 of 84 patients with SLE and 68 of 91 gender- and age-matched controls from the inclusion cohort participated. In addition, data on age, disease duration, disease activity and damage, as well as treatment...
Studies on cholesterol homeostasis by modulation of lipoproteins and bile acids
(2010-01-08)
treated with cholestyramine or chenodeoxycholic acid (CDCA). Following stimulation of bile acid synthesis with cholestyramine the mRNA levels for HNF4alpha were upregulated and positively correlated to the expression levels of CYP7A1, the rate limiting...
Cardiovascular disease in dementia
(2016-12-08)
The objective of this thesis was to characterize the burden of cardiovascular diseases in patients with dementia, their treatment and association with survival. Further, we aimed to explore whether cardiac structure in ...
The role of autophagy in anticancer therapy
(2018-08-24)
to screen the FIMM drug library consisting of 306 anticancer drugs and identified 104 autophagy modulators, of which 16 showed cell death potentiation upon siRNA mediated knock-down of ATG7 (autophagy-related protein 7) and VPS34 (vacuolar protein sorting 34...
Epidemiological and clinical aspects of fertility and diseases associated with infertility among Swedish-born and foreign-born women
(2007-05-18)
, EP, EM or infertility. In study 3, self-estimated alcohol consumption was obtained from postal questionnaires to 7,393 women in the age-range 18-28 years in 1969. Data on deliveries, miscarriages, legal abortions, EP, PID, EM and infertility...
Understanding cellular and cytoskeletal dysregulation in immunodeficiency diseases
(2019-12-18)
The immune system is a complex network of cells and molecules interacting to preserve the integrity and survival of the host by distinguishing self from non-self, and dysregulation of immune cells can lead to immunodeficiency, ...
Regulation of cellular responses to hypoxia by HIF-1alpha-dependent and -independent signaling pathways
(2012-08-13)
Hypoxia is a state of inadequate oxygen supply to the cells and tissues of the body. It plays a critical role in embryonic development, as well as in various physiological and pathological processes. Hypoxia-inducible ...