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T-cell mediated control of Epstein-Barr virus infection : viral mechanisms of immune escape
(1998-12-31)
-lymphocytes persist for life in healthy virus carriers. These infected cells express the EBV encoded nuclear antigen (EBNA)l but down-regulate other highly immunogenic viral products. We have shown that the glycine-alanine domain of EBNA1 generate a cis...
Significance of HIV-1 genetic subtypes
(1999-04-30)
The human immunodeficiency virus type 1 (HIV-1) displays high genetic variability. Phylogenetic studies have shown that a majority of HIV-1 sequences cluster into one large group called M (major), whereas a few are clearly distinct, group O (outlier...
Leishmania and HIV-1 interaction : immunopathogenic mechanisms
(1999-12-27)
relapse following successful initial response. Heat-inactivated (HI)-HIV-1 inhibited Leishmania-induced cell proliferation, but not IL-6 and TNF-[alpha] secretion, suggesting that the parasite can activate HIV. In addition, both HI and live HIV led...
Studies in DNA immunization
(1999-10-29)
This thesis describes investigations and developments of DNA immunization techniques, which were applied in the study of two different pathogens; HIV-1 and Chlamydia pneumoniae. DNA vaccines, i.e. naked plasmid DNA encoding an antigen, represent a...
Immunoglobulins in the adhesion of Plasmodium falciparum-infected erythrocytes in malaria
(2000-10-27)
anaemia.
It was suggested that immunoglobulins, bound to Plasmodium falciparum erythrocyte membrane protein 1, PfEMP1, is a co-receptor for adhesion of infected erythrocytes in the placenta. Immunoperoxidase staining of infected erythrocytes...
Suppressive DNA vaccination in experimental autoimmune encephalomyelitis
(1999-11-26)
)-EAE. Vaccination with DNA encoding MOG91-108 suppressed clinical signs of EAE, after MOG91-108-challenge.
In conclusion, vaccination with DNA encoding autoantigenic peptides suppresses EAE. Presence of ISS and a local type 1 cytokine milieu is decisive...
Mechanisms of immune escape in EBV associated malignancies : Hodgkin's disease and Burkitt's lymphoma
(1999-09-10)
express at least 3 viral proteins: the EBV nuclear antigen (EBNA)1, the latent membrane proteins (LMP)1 and LMP2A. LMP1 and LMP2A are targets for cytotoxic T lymphocyte (CTL) mediated responses. To examine whether EBV triggered reactivities can be detected...
Interaction between gastric pathogen Helicobacter pylori and host cells
(1999-08-09)
to viable versus fixed AGS cells was not significantly different. The observation that chloramphenicol, an inhibitor of bacterial protein synthesis and cycloheximide, an inhibitor of eukaryotic protein synthesis, significantly reduced adherence of type 1...
Early events of EBV mediated B cell transformation
(1998-12-24)
, the centroblasts of GC expressed cyclin D3 but not D2 as the BL tumors and lines.
The EBV infection of resting B cells in vitro induces an immunoblastic B cell phenotype. EBV-encoded LMP-1 is, at least in part, responsible for these phenotypic changes. We have...
Type-specific human papillomavirus antibodies : detection, characterization and application in seroepidemiology
(1999-11-05)
detected in cervical mucus samples. The most commonly detected isotypes of serum antibodies were IgG1 and IgA. Seropositivity for IgG or IgG1 correlated strongly with the life-time number of sexual partner, whereas positivity for IgA correlated more...