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Mechanisms regulating metabolic and mitogenic events in skeletal muscle : implications for insulin resistance and exercise
(2000-02-18)
Reduced glucose transport in skeletal muscle is a hallmark feature of Type II diabetes. Numerous mechanisms acutely or chronically regulate skeletal muscle glucose transport. The role of GLUT4, mitogen-activated protein ...
Molecular studies of hypothalamic food intake regulating systems and central myelination in two anorectic mouse models
(2016-05-20)
The aim of this thesis is to increase the understanding of the hypothalamic mechanisms that are vital for food intake regulation, in particular as it relates to anorexia, and the molecular mechanisms underlying myelination ...
Natural killer cells in cancer : studies on migration and cytotoxicity
(2014-05-08)
The role of natural killer (NK) cells in cancer development has been studied extensively over the last four decades and the increasing knowledge on NK cell regulation has improved both safety and efficacy of treatment. ...
Frizzled as a G protein-coupled receptor : the role of disheveled and G proteins for signal specification
(2013-08-16)
Cell communication governed and coordinated by the WNT family of lipoglycoproteins comprises essential physiological processes active throughout the life-span of metazoan organisms. In humans, severe diseases and congenital ...
Therapeutic response in human cancers : the dual role of STAT signalling
(2016-08-08)
STAT proteins were discovered as the mediators of interferon (IFN) signalling in response to viral infections. Later, it has become evident that STATs are activated by many stimuli and that they exert multifaceted effects ...