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The role of PDGFB in dermatofibrosarcoma protuberans and giant cell fibroblastoma
(2000-02-18)
Dermatofibrosarcoma protuberans (DFSP) and giant cell fibroblastoma (GCF) are rare invasive tumors of the dermis. GCF is considered the juvenile form of DFSP. Both DFSP and GCF are characterized by the presence of chromosomal ...
Linking innate and adaptive immunity to streptococcus pneumoniae
(2012-09-05)
Streptococcus pneumoniae (the pneumococcus) most commonly colonizes the human nasopharyngeal mucosa without causing any symptoms. However, this organism has the potential to spread to normally sterile sites and cause ...
Synaptic uncoupling in the mouse cochlea induced by noise or cisplatin and its clinical relevance
(2020-03-12)
The cochlea has an autonomous circadian clock that controls auditory function and increases vulnerability to noise trauma during the active phase. The mechanisms regulating the circadian control of the auditory system are ...
Understanding inflammatory mechanisms in rheumatic diseases
(2014-11-05)
Rheumatoid arthritis (RA), Psoriasis (Ps) and Psoriasis arthritis (PsA) are chronic inflammatory autoimmune disorders, where primary targets are peripheral joints, skin and skin/joints respectively. Both innate and adaptive ...
Leukotriene A4 hydrolase : identification of amino acid residues involved in catalyses and substrate-mediated inactivation
(2001-09-14)
Leukotriene (LT) A4 hydrolase catalyzes the committed step in the
biosynthesis of LTB4, a classical chemoattractant and immuine-modulating
lipid mediator involved in inflammation, host-defense against infections,
and ...
Detecting novel effects of exercise or AMPK activation in human skeletal muscle
(2018-04-24)
Cardiovascular and metabolic disorders are among the main causes of death today. Regular exercise can prevent and treat these chronic diseases. A molecule at the center of exercise adaptations in skeletal muscle is adenosine ...
Molecular mechanisms of cardiovascular calcification
(2019-05-23)
Cardiovascular calcification is a pathophysiological process characterized by the deposition of calcium-phosphate crystals in the arteries and the leaflets of the heart valves. In the arteries calcification causes arterial ...
Healthcare financing challenges and opportunities to achieving universal health coverage in the low- and middle-income country context
(2020-02-05)
Background: In Bangladesh, on an average 62% of total healthcare spending was borne by households through out-of-pocket (OOP) payments annually during 2000- 2015. Because of such high OOP payments, a sizeable proportion of households (15.7%) faced...
Investigating the pathological heart and its regenerative potential
(2018-07-31)
Cardiovascular disease is a leading contributor to mortality the world over, affecting millions of people each year. This, combined with its associated monetary and societal costs, has made the investigation of the etiology ...
Association between diet and treatment results in patients with rheumatoid arthritis and systemic lupus erythematosus
(2016-11-07)
Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are chronic autoimmune inflammatory diseases. The causes of these diseases are unknown and evidence indicates that a combination of both genetic and environmental ...