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A clinical and experimental study of basal cell carcinoma : aspects on epidemiology, genetics and microphysiology
(2000-01-14)
In the present thesis we report on basal cell carcinoma from the points of view of its incidence, risk factors and pathogenesis, with special interest in patients with more than one basal cell carcinoma in life.
Incidence ...
Atrial fibrillation and lifestyle factors with focus on physical activity and alcohol consumption
(2017-02-06)
The overall aim of this thesis was to investigate how modifiable lifestyle factors, with a focus on alcohol consumption and physical activity, influence the risk of atrial fibrillation (AF). The thesis is based on data ...
Cellular mechanisms of human muscle fatigue and disease-related loss of muscle function
(2020-08-27)
A loss of skeletal muscle function and mass is a hallmark of several diseases resulting in a dismal life quality and poor prognosis. Impaired intracellular Ca2+-handling has been proposed as an underlying cause of these ...
Proteolysis of insulin-like growth factor-binding protein-1, -2 and -4 : function of fragments
(2011-12-21)
, IGFBP-2 and IGFBP-4. IGFBP-1 bound to IGF-I was also degraded whereas IGF-II was shown to have an inhibitory effect on proteolysis of IGFBP-1. The proteolytically active preparation of neutrophil-derived azurocidin was found to be glycosylated...
Cost analysis and policy implications in psychiatric care
(2009-04-01)
in Sweden in 2001 (Study I) was estimated at MSEK 85 774 (M€ 9 426, €1= SEK9.1). Indirect costs were totally predominant and constituted about 80% of the total cost, i.e. production losses due to early retirement, sickness absence and premature death...
Mortality and co-morbidity among patients with hemochromatosis and their first-degree relatives
(2010-05-14)
Genetic hemochromatosis (GH) is an autosomal recessive disease caused by
a C282Y mutation in the HFEgene, and is characterized by excess iron
accumulation in multiple organs. Classical manifestations of GH include
liver ...
New molecular tools for prenatal diagnosis
(2016-10-04)
parallel sequencing of 79 genes associated with heart disease. Sixty-two cases (21.4%) had putative pathogenic variants in genes associated with channelopathies (53%), cardiomyopathies (24%) or congenital heart defects (23%). Screening for pathogenic...
Responsive nanostructured materials for bioanalyte detection and triggered antimicrobial therapy
(2022-04-29)
to refer to total NH3 and NH+ 4 levels) which is an important diagnostic bioanalyte. Ammonia production by urease producing gut bacteria is a major contributor to blood ammonia levels and must be effectively detoxified by the liver for excretion...
Exosomes : the future of vaccination?
(2011-11-25)
to increase immunogenicity of exosomes, and 3) studying the relevance of exosomes in a human inflammatory disease, atopic eczema (AE). We report that exosomes from murine bone marrow-derived dendritic cells (DCs) can induce CD4+ T cell responses in a B cell...
Type 1 diabetes in pregnancy : perinatal outcome with special reference to fetal macrosomia
(2012-04-16)
.2 million controls we found significantly increased risks of all adverse outcomes in women with T1DM: adjusted odds ratios: severe preeclampsia: 4.47 (3.77-5.31), Caesarean delivery: 5.31 (4.97-5.69), stillbirth: 3.34 (2.46- 4.55), perinatal mortality: 3...