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On the structure and contents of occupational therapist paradigms : empirical studies of occupational therapy students' and occupational therapists' views on occupational therapy
(2000-03-24)
The ambition of this thesis is to contribute, from a paradigm theoretical frame of reference, to the development of occupational therapy knowledge in Sweden.
The specified thesis aim was to identify and characterize ...
Toll-like receptor-induced cytokine secretion by human monocytes in healthy donors and septic patients assessed at the single cell level
(2013-08-23)
assay. Cytokines (IL-1β, IL-6, IL-10, IL-12p40, TNF-α, GM-CSF) and chemokines (IL-8, MIP-1β) important in inflammatory processes were assessed. Granulocytes were found to selectively secrete IL-8 and MIP-1β. Also TNF-α was secreted but by considerably...
Chromatin remodelers and their roles in chromatin organization
(2012-11-20)
The DNA in the eukaryotic nucleus is organized into a complex DNA-protein structure called chromatin. The basic repeating unit of chromatin is the nucleosome, which consists of 147 bp of DNA wrapped around a histone protein ...
Functional and bioinformatical studies of the TGFb superfamily : identification and characterization of ALK7
(2001-11-02)
The transforming growth factor beta (TGFbeta) superfamily of polypeptide
growth factors encompasses more than 30 diverse mammalian members. They
are involved in most cellular processes, ranging from cell proliferation
and ...
Dietary effects on gene regulation and function in human adipose tissue in obesity
(2007-05-04)
Obesity is an excess of body fat that develops from both genetic and environmental factors, leading to a disturbed balance between energy intake and energy expenditure. It is closely associated with insulin resistance, ...
Using enriched quality register data for health care evaluation : examples from rheumatoid arthritis
(2014-09-24)
Swedish registers have for decades successfully been used for medica research, enabling long-term follow-up of large patient cohorts using observational designs. With a tax funded health care system and the use of a personal ...
Trajectory mapping of human embryonic stem cell cardiogenesis reveals lineage branch points and an ISL1 progenitor-derived cardiac fibroblast lineage
(2021-02-17)
and in vitro. Both myogenic and nonmyogenic populations express ISL1, and its loss redirected myogenic progenitors into a neural-like fate. Our study provides important insights into processes during early heart development....
Coronary prevention in two European areas with different risk levels, Stockholm and Sicily : doctors' risk judgments and statin utilization
(2014-04-24)
Introduction: International guidelines on the primary prevention of cardiovascular disease recommend that preventive measures should be based on the doctors’ quantitative total risk assessment of the patient. Treatment is ...