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Interindividual differences in xenobiotic-metabolising enzymes : the human genetic factor
(1999-12-31)
glutathione S-transferase gene, GSTM1, is polymorphic in humans with roughly half of the population being homozygous deleted for this gene. In contrast, an earlier Saudi Arabian GSTM1 phenotyping study revealed that some individuals exhibited ultrarapid enzyme...
Oxygen-dependent regulation of HIF-1alpha expression and function
(2009-09-04)
that mediate adaptive cellular responses to hypoxia by activating the transcription of target genes. HIF is a heterodimer consisting of an oxygen-regulated alpha subunit and a constitutively expressed HIF-1beta (ARNT) subunit. Both HIF subunits belong to the b...
Molecular adaptations of skeletal muscle in health and disease
(2019-10-17)
and that repeated exposure to SIT provides some protection from SIT-induced RyR1 modifications. We moreover show that a three-week SIT program improves exercise performance but does not accelerate recovery of neuromuscular function after SIT. In the second paper, we...
Oxygen sensing in myeloid cells : implications for physiology and cancer
(2020-07-31)
presentation, a process important for lymphocyte activation. Finally, in endotoxin induced sepsis, our studies demonstrated that removal of HIF-1α leads to decreased hypoglycemia due to reduced glycolysis. The strongest reduction in glycolysis was observed...
Oxidoreductases and RNA degradosome controlling virulence-associated traits of Salmonella enterica serovar Typhimurium
(2013-09-04)
tolerance and in virulence of S. Typhimurium. We demonstrated that ScsABCD proteins are dispensable for invasion in cultured epithelial cells under normal invasive conditions, although ScsABCD acts as a suppressor of SPI-1 mediated invasion upon oxidative...
SUMO and ubiquitin : the yin and yang of IGF-1R function
(2007-10-04)
Tumorigenesis is a multistep process involving genetic and epigenetic
alterations that drive the progressive transformation of normal human
cells into highly malignant derivatives. The insulin-like growth factor 1
receptor ...
Visual function in very low birth weight adolescents : fifteen-year follow-up of children in southeast Sweden
(2009-01-23)
Background: Very low birth weight (VLBW < 1500 g) carries an increased risk of visual and cognitive deficits. Long term follow-up studies are sparse. The associations between neural structure and visual and cognitive outcome ...
Exploring the transcriptome of the brain
(2014-05-14)
Our knowledge of the transcriptome has become much more complex since the days of the central dogma of molecular biology. We now know that splicing takes place to create potentially thousands of isoforms from a single gene, ...