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A bio-psychological analysis of functional gastrointestinal disorders and a clinical trial of its treatment using psychodrama
(1999-11-17)
, after the treatment and at the three-year follow-up. They were recruited from a catchment area in the southern parts of Stockholm. The group consisted of 17 women and 5 men. Mean age was 47 years. The control group consisting of 28 patients was recruited...
Drug treatment in children with focus on off-label drug use
(2010-08-06)
There is a lack of paediatric documentation concerning efficacy and
safety of many drugs, which contribute to drug use outside the terms of the product license (off-label). In the present thesis, four studies (I-IV), using ...
Structure-function studies of plasminogen activator inhibitor-1
(1998-11-20)
Plasminogen activator inhibitor-I (PAI-1) is an important physiological inhibitor of tissue-type plasminogen activator (tPA) and urine-type plasminogen activator (uPA). High plasma levels of PAI-1 correlate to thrombotic ...
Physiological status of bacteria used for environmental applications
(2006-12-22)
bacterial
luciferase) or luc (encoding eukaryotic luciferase). Viability stains,
5-cyano-2,3-ditolyl-tetrazolium chloride (CTC) and propidium iodide (PI),
were used to stain active and dead cells, respectively. The marker-gene
tagged cells were incubated...
Hormonal regulation of HES-1 in breast cancer cells
(2008-05-21)
that exogenous expression of HES-1 causes cell cycle arrest in the G1 phase of the cell cycle. We found the cell cycle factor E2F-1, critical for G1 to S-phase progression, to be regulated by HES-1, via a cis-element in the 5 regulatory region of the E2F-1 gene...
Dissecting the roles of viral T-antigens in Merkel cell carcinoma
(2022-04-11)
Merkel cell carcinoma (MCC) is a rare but aggressive form of skin malignancy with increasing incidence. Merkel cell polyomavirus (MCPyV) is associated with ~80% of MCCs, and a minority is caused by ultra-violet (UV)-induced ...
Interleukin-22 binding protein in multiple sclerosis and experimental inflammation models
(2017-10-20)
Multiple sclerosis (MS) is the leading cause of non-traumatic neurological disability in young adults. Although the cause of the disease is unknown, several genetic and environmental risk factors have been identified. By ...