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Quantitative analysis of DNA adducts formed by some epoxides of industrial importance
(1999-10-22)
The work presented herein has focused on DNA adduct formation by three industrial epoxides, allyl glycidyl ether, propylene oxide and epichlorohydrin. Epoxides, owing to the strained oxirane ring are chemically reactive ...
PET studies of the serotonin system in major depression and its treatment
(2014-10-03)
The serotonin system has been implicated in major depression since the
1960s, mainly based on the serotonin enhancing properties of
antidepressants. Positron emission tomography, PET, is the in vivo
molecular imaging ...
Studies of the tumor-vasculature interface : role of TGF-beta 1-induced epithelial to mesenchymal transition
(2013-01-28)
deletion of the CAR gene (Cxadr) from E12.5 during mouse development leads to subcutaneous edema, hemorrhage and embryonic death. The lymphatic vessels in CAR-deficient mice were dilated and structurally abnormal with the presence of gaps and holes...
Breathe (in the air) : pulmonary immunology in multiple sclerosis
(2018-02-28)
hESC, as well as being able to cluster and separate different cell types. The method implemented a masking strategy to efficiently limit capture of the highly abundant 5.8S rRNA, and incorporation of a unique molecular identifier allowed...
Genes of the serotonergic system and susceptibility to psychiatric disorders : a gene-based haplotype approach
(2006-05-24)
Psychiatric disorders are complex, non-mendelian disorders. Complex disorders are ultimately determined by a number of genetic and environmental factors, and the effect of each factor may be obscured or confounded by others. ...
Molecular insights into Hutchinson-Gilford progeria syndrome and age-associated disease : from mechanisms to treatment strategy
(2019-08-30)
Aging is a complex process that occurs as we grow old and is associated with a gradual decline of tissue functions. Scientists have been trying to understand the mechanisms that drive such phenomenon by studying premature ...
Towards personalized immunotherapy : development of in vitro models for imaging natural killer cell behavior in the tumor microenvironment
(2022-01-27)
for my doctoral work. In Chapter 5, I describe the methods we developed to culture tumor spheroids in vitro using ultrasonic standing waves in microwell chips, focusing on the theory, design, and applications. Chapter 6 and Chapter 7 focus...
Coronary prevention in two European areas with different risk levels, Stockholm and Sicily : doctors' risk judgments and statin utilization
(2014-04-24)
Introduction: International guidelines on the primary prevention of cardiovascular disease recommend that preventive measures should be based on the doctors’ quantitative total risk assessment of the patient. Treatment is ...
Experimental spinal cord injury : methodological and neuroimmunological contributions with some historical background
(2011-01-19)
Spinal cord injury (SCI) is an incurable neurotraumatic catastrophe that afflicts mostly young individuals with resultant functional impairment of varying degrees of severity. The single pharmacologic treatment option at ...