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Chronic hepatitis B : immunological, virological and clinical aspects in the natural course and during the combined prednisolone and interferon-alpha-2b therapy
(1999-11-15)
The aims of this study were to characterize the IgM and IgG antibody responses to well-defined B-cell epitopes within the preS2 region of the HBV envelope proteins in sera from Chinese and Caucasian patients with chronic ...
Sex and gender aspects on intensive care : access, intensity and outcome
(2021-05-06)
There is an underlying assumption in society that critically ill patients are admitted to an intensive care unit (ICU) based on their illness severity coupled with their comorbidities, and that other variables are irrelevant. ...
Generation and investigation of neural microenvironment in health and disease
(2019-10-09)
Cells in our body are under the constant influence of intrinsic and extrinsic factors that modulate their behavior. Early on, starting during the development of the organism, growth factors, nutrients, oxygen, the extracellular ...
Unifying viral evolution and immunological patterns to investigate risk of HIV-1 disease progression
(2012-11-27)
After 30 years of research, the exact mechanisms underlying human immunodeficiency virus type 1 (HIV-1) pathogenesis and disease progression remain elusive. In the absence of highly active antiretroviral therapy, most ...
Optimization of HIV and tuberculosis co-treatment in Tanzanian patients : emphasis on pharmacogenetics and drug interactions
(2013-03-22)
Treatment of HIV and its comorbidities particularly tuberculosis is complicated by wide inter-individual variations in drug exposure due to drug-interactions and variable expressions of drug metabolizing enzymes and ...
Dissecting the roles of viral T-antigens in Merkel cell carcinoma
(2022-04-11)
of miRNAs. These miRNAs suppressed autophagy by targeting the key autophagy genes ATG7, SQSTM1 and BECN1. Concordantly, low expressions of ATG7 and SQSTM1 were lower in virus-positive tumors. In addition, treatment with Torin-1 (mTOR inhibitor) induced...
Healthcare financing challenges and opportunities to achieving universal health coverage in the low- and middle-income country context
(2020-02-05)
Background: In Bangladesh, on an average 62% of total healthcare spending was borne by households through out-of-pocket (OOP) payments annually during 2000- 2015. Because of such high OOP payments, a sizeable proportion of households (15.7%) faced...
Sex differences in cancer risk and survival
(2019-11-15)
.05; 95% CI, 1.02-1.1 (lung adenocarcinoma) to 8.0; 95% CI, 7.5-85 (laryngeal cancer). Women with non-small cell lung cancer (study II) are younger, smoke less, and present better performance status, compared to men. Women with lung adenocarcinoma...
Novel measure of olfactory bulb function in health and disease
(2021-05-26)
Present neuroimaging techniques are capable of recording the neural activity from all over the brain but the olfactory bulb (OB). The OB is the first olfactory processing stage of the central nervous system and the site ...
An object's smell in the multisensory brain : how our senses interact during olfactory object processing
(2021-05-28)
Object perception is a remarkable and fundamental cognitive ability that allows us to interpret and interact with the world we are living in. In our everyday life, we constantly perceive objects–mostly without being aware ...