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Molecular and cellular mechanisms during adherence and cell signaling of pathogenic Neisseria to host cells
(1999-11-11)
cells.
The primary interaction between a pilus and its host cell receptor CD46 results in transient release of Ca2+ from intracellular stores. The Ca2+ -flux and the bacterial adherence was inhibited by chelators of intracellular calcium. In addition...
Developmental origins of polycystic ovary syndrome : role of early adverse life events on adult health
(2020-03-17)
The research focus of this thesis is polycystic ovary syndrome (PCOS), the most common endocrine disorder among women of reproductive age, associated with reproductive, cardio-metabolic, and mental health complications. ...
Endogenous thrombospondin-1 and proteases in the regulation of lymphocyte adhesion and motility
(2008-09-26)
of MMPs (TIMP-1) and ability to infiltrate a threedimensional (3D) gel of extracellular (ECM) components. However, cell migration to two-dimensional (2D) ECM-components was not correlated to MMP-9/TIMP-1 expression. The role for MMP-9 and TIMP-1...
Insulin signalling and TBC1D1 in skeletal muscle metabolism
(2011-11-18)
Type 2 diabetes mellitus (T2DM) has taken the form of a pandemic disease globally as people adopt a more western lifestyle. High circulating glucose levels indicates that an individual is in the risk zone for developing T2DM. One of the hallmarks...
Mathematical modelling of insulin signalling : effects on glucose metabolism in skeletal muscle
(2010-04-13)
The use of models to understand complex phenomena is indispensable to the
scientific community. The advantage of a model is that it simplifies the
phenomena under study. However, a model should be only as complex ...
On antidepressant effects of running and SSRI : focus on hippocampus and striatal dopamine pathways
(2007-05-25)
Considering the heterogeneous character of depression, it seems likely
that many brain regions are involved mediating the diverse symptoms of
depression. For example, the mesolimbic DA system has a central function
for ...
Mental and physical health among first-generation and second-generation immigrants in Sweden
(2006-09-11)
-generation immigrants and whether having one parent born in Sweden has a protective effect on this risk (study 2). To examine whether the increased risk of being hospitalized for alcohol and drug abuse among certain immigrant groups is present among second...
Pituitary regulation of plasma lipoprotein metabolism and intestinal cholesterol absorption
(2005-11-18)
Increased levels of plasma cholesterol are associated with a higher risk to develop atherosclerosis, the leading cause of death in Western societies. The major part of cholesterol in human blood is transported within ...
Human muscle response to sprint exercise and nutrient supply with focus on factors related to protein metabolism
(2016-12-21)
of essential amino acids and carbohydrates increases the amino acid sensor Vps34 activity, the amino acid transporter and sensor SNAT2, Akt/mTOR signalling and consequently enhances the rate of muscle protein synthesis in skeletal muscle following sprint...
Oxidoreductases and RNA degradosome controlling virulence-associated traits of Salmonella enterica serovar Typhimurium
(2013-09-04)
The oxidative stress response is a fundamental and primitive mode of innate immune defense in nearly all forms of life. The host oxidative stress response becomes truly important and effective especially against intracellular ...